Estimation of Hepatic Proton-Density Fat Fraction by Using MR Imaging at 3.0 T
Estimation of Hepatic Proton-Density Fat Fraction by Using MR Imaging at 3.0 T
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DOI：
10.1148/radiol.10100659
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发表时间：
2011-03-01
期刊：
影响因子：
19.7
通讯作者：
Sirlin, Claude B.
中科院分区：
文献类型：
--
作者：
Yokoo, Takeshi;Shiehmorteza, Masoud;Sirlin, Claude B.
目的：为了比较几个磁共振（MR）成像为基础的方法在3.0 T的肝脏质子密度脂肪分数（FF）估计的准确性，光谱作为参考technique.Materials和Methods：这项前瞻性研究是机构审查委员会批准和符合HIPAA。已获得知情同意。163例受试者（39例已知肝脂肪变性，110例有脂肪变性风险因素，14例无风险因素）接受了质子MR波谱和非T1加权梯度回波MR成像。在光谱学中，参考FF由脂肪和水质子密度的频率选择性测量确定。在成像时，FF通过使用二、三或六回波方法计算，具有单频和多频脂肪信号建模。三回波法和六回波法校正了T2*;双回波法没有。对于每种成像方法，通过使用成像FF和光谱FF之间的线性回归来评估脂肪估计准确度。结果：二回波法、三回波法和六回波法的回归截距分别为-0.0211，0.0087和-0.0062（P
Purpose: To compare the accuracy of several magnetic resonance (MR) imaging-based methods for hepatic proton-density fat fraction (FF) estimation at 3.0 T, with spectroscopy as the reference technique.Materials and Methods: This prospective study was institutional review board approved and HIPAA compliant. Informed consent was obtained. One hundred sixty-three subjects (39 with known hepatic steatosis, 110 with steatosis risk factors, 14 without risk factors) underwent proton MR spectroscopy and non-T1-weighted gradient-echo MR imaging of the liver. At spectroscopy, the reference FF was determined from frequency-selective measurements of fat and water proton densities. At imaging, FF was calculated by using two-, three-, or six-echo methods, with single-frequency and multifrequency fat signal modeling. The three-and six-echo methods corrected for T2*; the two-echo methods did not. For each imaging method, the fat estimation accuracy was assessed by using linear regression between the imaging FF and spectroscopic FF. Binary classification accuracy of imaging was assessed at four reference spectroscopic thresholds (0.04, 0.06, 0.08, and 0.10 FF).Results: Regression intercept of two-, three-, and six-echo methods were -0.0211, 0.0087, and -0.0062 (P