Ephedrine activates brown adipose tissue in lean but not obese humans
Ephedrine activates brown adipose tissue in lean but not obese humans
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DOI：
10.1007/s00125-012-2748-1
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发表时间：
2013-01-01
期刊：
影响因子：
8.2
通讯作者：
Kingwell, B. A.
中科院分区：
文献类型：
--
作者：
Carey, A. L.;Formosa, M. F.;Kingwell, B. A.
棕色脂肪组织(BAT)的激活增加了能量消耗，可能有助于肥胖的治疗。冷暴露是蝙蝠产热的主要生理刺激，而支配蝙蝠的交感神经系统在这一过程中是必不可少的。然而，在肥胖的人中，寒冷诱导的BAT激活受到了损害。为了探索BAT的治疗潜力，必须确定药物是否能激活BAT。我们的目的是确定在急性给予口服生物可用交感神经后，瘦人和肥胖者是否可以激活BAT。在一项随机、双盲、交叉试验中，我们给9名瘦(BMI 22+/-1 kg/m(2))和9名肥胖(BMI 36+/-1 kg/m(2))年轻男性口服2.5 mg/kg麻黄素。在另一天，同样的参与者服用了安慰剂。通过用[F-18]氟脱氧葡萄糖和正电子发射断层扫描-计算机断层成像测量葡萄糖摄取来评估BAT活性。与安慰剂相比，服用麻黄素的瘦肉者BAT活性增加，但肥胖者BAT活性没有变化。与安慰剂相比，服用麻黄素后BAT活性的变化与身体肥胖的各种指数呈负相关。BAT可以通过急性口服交感神经麻黄素激活，但在肥胖者则不能。
Brown adipose tissue (BAT) activation increases energy consumption and may help in the treatment of obesity. Cold exposure is the main physiological stimulus for BAT thermogenesis and the sympathetic nervous system, which innervates BAT, is essential in this process. However, cold-induced BAT activation is impaired in obese humans. To explore the therapeutic potential of BAT, it is essential to determine whether pharmacological agents can activate BAT.We aimed to determine whether BAT can be activated in lean and obese humans after acute administration of an orally bioavailable sympathomimetic. In a randomised, double-blinded, crossover trial, we administered 2.5 mg/kg of oral ephedrine to nine lean (BMI 22 +/- 1 kg/m(2)) and nine obese (BMI 36 +/- 1 kg/m(2)) young men. On a separate day, a placebo was administered to the same participants. BAT activity was assessed by measuring glucose uptake with [F-18]fluorodeoxyglucose and positron emission tomography-computed tomography imaging.BAT activity was increased by ephedrine compared with placebo in the lean, but unchanged in the obese, participants. The change in BAT activity after ephedrine compared with placebo was negatively correlated with various indices of body fatness.BAT can be activated via acute, oral administration of the sympathomimetic ephedrine in lean, but not in obese humans.