Evolution of deep gray matter volume across the human lifespan
Evolution of deep gray matter volume across the human lifespan
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DOI：
10.1002/hbm.23604
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发表时间：
2017-08-01
影响因子：
4.8
通讯作者：
Beaulieu, Christian
中科院分区：
文献类型：
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作者：
Narvacan, Karl;Treit, Sarah;Beaulieu, Christian
皮层下灰质结构的磁共振成像介导行为、认知和多种疾病的病理生理学，对于建立人类一生中的典型成熟模式至关重要。这项单中心研究检查了 3 个健康队列的 T1 加权 MPRAGE 图像：(i) 406 名年龄 5-83 岁受试者的横断面队列； (ii) 由 84 名受试者组成的纵向神经发育队列，扫描两次，间隔约 4 年，第一次扫描时年龄为 5-27 岁； (iii) 由 55 名受试者组成的纵向老龄队列，扫描两次，间隔约 3 年，第一次扫描时年龄为 46-83 岁。来自纵向受试者的第一次扫描被纳入横断面分析中。丘脑、尾状核、壳核、苍白球、伏核、海马和杏仁核体积的年龄依赖性变化在横截面队列中使用泊松、二次和线性模型进行测试，在纵向队列中使用二次和线性模型进行测试。大多数深层灰质结构在横截面队列中最适合泊松回归，在年轻纵向队列中最适合二次曲线，而在纵向老龄队列中，除尾状核和苍白球外的所有结构的体积均呈线性下降。对于所有皮质下结构，男性的体积都比女性大，但随年龄变化的轨迹的性别差异并不显着。受试者内分析显示，65%-80% 的 13-17 岁青少年在两次扫描之间（大约相隔 4 年）壳核、苍白球和海马体的体积出现纵向减小，这表明青春期存在独特的发育过程。这项针对健康参与者的寿命研究将为与神经和精神疾病进行比较奠定基础。 Hum Brain Mapp 38:3771-3790, 2017。(c) 2017 Wiley periodicals, Inc.
Magnetic resonance imaging of subcortical gray matter structures, which mediate behavior, cognition and the pathophysiology of several diseases, is crucial for establishing typical maturation patterns across the human lifespan. This single site study examines T1-weighted MPRAGE images of 3 healthy cohorts: (i) a cross-sectional cohort of 406 subjects aged 5-83 years; (ii) a longitudinal neurodevelopment cohort of 84 subjects scanned twice approximately 4 years apart, aged 5-27 years at first scan; and (iii) a longitudinal aging cohort of 55 subjects scanned twice approximately 3 years apart, aged 46-83 years at first scan. First scans from longitudinal subjects were included in the cross-sectional analysis. Age-dependent changes in thalamus, caudate, putamen, globus pallidus, nucleus accumbens, hippocampus, and amygdala volumes were tested with Poisson, quadratic, and linear models in the cross-sectional cohort, and quadratic and linear models in the longitudinal cohorts. Most deep gray matter structures best fit to Poisson regressions in the cross-sectional cohort and quadratic curves in the young longitudinal cohort, whereas the volume of all structures except the caudate and globus pallidus decreased linearly in the longitudinal aging cohort. Males had larger volumes than females for all subcortical structures, but sex differences in trajectories of change with age were not significant. Within subject analysis showed that 65%-80% of 13-17 year olds underwent a longitudinal decrease in volume between scans (approximate to 4 years apart) for the putamen, globus pallidus, and hippocampus, suggesting unique developmental processes during adolescence. This lifespan study of healthy participants will form a basis for comparison to neurological and psychiatric disorders. Hum Brain Mapp 38:3771-3790, 2017. (c) 2017 Wiley Periodicals, Inc.