Neighboring Genes Show Interchromosomal Colocalization after Their Separation
Neighboring Genes Show Interchromosomal Colocalization after Their Separation
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相邻基因在分离后表现出染色体间共定位
DOI：
10.1093/molbev/msu065
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发表时间：
2014-05-01
影响因子：
10.7
通讯作者：
Dai, Xianhua
中科院分区：
文献类型：
--
作者：
Dai, Zhiming;Xiong, Yuanyan;Dai, Xianhua
真核生物染色体上的基因顺序是非随机的。一些邻近基因在物种间表现出顺序守恒，而一些邻近基因在进化过程中出现分离。在这里，我们研究了邻近基因在分离后是否表现出相互作用。我们发现相邻的基因对在它们分离的物种中往往表现出染色体间共定位（即核共定位）。这些核共定位的分离邻近基因对1)在更多的物种中表现出邻域保护，2)倾向于受相同的转录因子调控，3)倾向于受相同的组蛋白修饰调控。这些结果表明邻近基因在分离后仍能保持核接近的机制。
The order of genes on eukaryotic chromosomes is nonrandom. Some neighboring genes show order conservation among species, while some neighboring genes separate during evolution. Here, we investigated whether neighboring genes show interactions after their separation. We found that neighboring gene pairs tend to show interchromosomal colocalization (i.e., nuclear colocalization) in the species in which they separate. These nuclear colocalized separated neighboring gene pairs 1) show neighborhood conservation in more species, 2) tend to be regulated by the same transcription factor, and 3) tend to be regulated by the same histone modification. These results suggest a mechanism by which neighboring genes could retain nuclear proximity after their separation.