The importance of drug combinations for effective control of hypertension
The importance of drug combinations for effective control of hypertension
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DOI：
10.3109/10641969909061016
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发表时间：
1999-07-01
影响因子：
12.3
通讯作者：
Chalmers, J
中科院分区：
文献类型：
--
作者：
Chalmers, J
大多数高血压患者需要至少两种药物才能将血压控制在140/90 mmHg以下，因此需要联合用药。重要性；纵向研究表明，达到的血压是结果的主要决定因素，并且从一些国家的人口调查显示，一般情况下，不到30%的接受治疗的高血压患者的血压低于140/90 mmHg。良好的抗高血压药物组合使用具有不同主要作用的不同类别的药物，使降压效果完全叠加，同时将副作用降到最低。联合用药治疗高血压的特殊价值在于它允许使用低剂量，这反过来又提高了治疗的依从性和高血压的控制。本文讨论了老年人原发性高血压和收缩期高血压的有效联合治疗，并探讨了其潜在的治疗方法；固定低剂量组合的优点。
The need for drug combinations in the management of hypertension arises from the fact that the majority of hypertensive patients-need at least two drugs to control the blood pressure to below 140/90 mmHg. The importance of;achieving such goal blood pressures is emphasised by longitudinal studies demonstrating that the achieved blood pressure is the main determinant of outcome and from population surveys in a number of countries that reveal that in general, less than 30% of treated hypertensive patients have brood pressures below 140/90 mmHg.Good combinations of antihypertensive drugs use agents from different classes with different primary actions so that the hypotensive effects are fully additive while side effects are minimised. The particular value of combining drugs for treating hypertension is that it permits the use of low doses, which in turn improves adherence to therapy and control of hypertension. Effective combinations for the treatment of essential hypertension and of systolic hypertension in the elderly are discussed, as are the potential; advantages of fixed low dose combinations.