Synthesis and evaluation of Janus type nucleosides as potential HCV NS5B polymerase inhibitors.

Synthesis and evaluation of Janus type nucleosides as potential HCV NS5B polymerase inhibitors.
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DOI:
10.1016/j.bmcl.2013.03.077
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发表时间:
2013-06-01
影响因子:
2.7
通讯作者:
Schinazi, Raymond F.
Schinazi, Raymond F.
中科院分区:
医学4区
文献类型:
--
作者:
Zhou, Longhu;Amblard, Franck;Zhang, Hongwang;McBrayer, Tamara R.;Detorio, Mervi A.;Whitaker, Tony;Coats, Steven J.;Schinazi, Raymond F.

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The synthesis of new ribo and 2’-β-C-methyl ribo Janus type nucleosides J-AA, J-AG and J-AU is reported along with their ability to block HCV and HIV replication. Their toxicity was also assessed in Huh7, human lymphocytes, CEM and Vero cells
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