Synthesis and evaluation of Janus type nucleosides as potential HCV NS5B polymerase inhibitors.
Synthesis and evaluation of Janus type nucleosides as potential HCV NS5B polymerase inhibitors.
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DOI:
10.1016/j.bmcl.2013.03.077
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发表时间:
2013-06-01
影响因子:
2.7
通讯作者:
Schinazi, Raymond F.
中科院分区:
文献类型:
--
作者:
Zhou, Longhu;Amblard, Franck;Zhang, Hongwang;McBrayer, Tamara R.;Detorio, Mervi A.;Whitaker, Tony;Coats, Steven J.;Schinazi, Raymond F.
The synthesis of new ribo and 2’-β-C-methyl ribo Janus type nucleosides J-AA, J-AG and J-AU is reported along with their ability to block HCV and HIV replication. Their toxicity was also assessed in Huh7, human lymphocytes, CEM and Vero cells
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影响因子:
7.3
作者:
Wang, GY;Tam, RC;Pai, B
通讯作者:
Pai, B
影响因子:
2.7
作者:
Ding, YL;An, HY;Girardet, JL
通讯作者:
Girardet, JL
影响因子:
7.3
作者:
Clark, JL;Hollecker, L;Pankiewiez, KW
通讯作者:
Pankiewiez, KW
影响因子:
29.4
作者:
Kanwal F;Hoang T;Kramer JR;Asch SM;Goetz MB;Zeringue A;Richardson P;El-Serag HB
通讯作者:
El-Serag HB
影响因子:
7.3
作者:
CHUNG, FL;SCHRAM, KH;TOWNSEND, LB
通讯作者:
TOWNSEND, LB