Coronary heart disease mortality among young adults in the US from 1980 through 2002
Coronary heart disease mortality among young adults in the US from 1980 through 2002
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DOI：
10.1016/j.jacc.2007.05.056
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发表时间：
2007-11-27
影响因子：
24
通讯作者：
Capewell, Simon
中科院分区：
文献类型：
--
作者：
Ford, Earl S.;Capewell, Simon
本研究的目的是研究冠心病（CHD）的年龄特异性死亡率，特别是年轻人的死亡率。背景：年轻人中肥胖、糖尿病、血压和代谢综合征的趋势引起了人们对这一群体冠心病死亡率的关注。方法：我们使用1980年至2002年的死亡率数据来计算美国35岁成人冠心病的年龄特异性死亡率。结果总体而言，年龄调整死亡率在男性中下降了52%，在女性中下降了49%。在35岁至54岁的妇女中，1980年至1989年死亡率估计年百分比变化（EAPC）为-5.4%(95%可信区间[Cl] -5.8至-4.9)，1989年至2000年为-1.2% (95% CI -1.6至-0.8)，2000年至2002年为1.5% （95% CI -3.4至6.6）。在35岁至54岁的男性中，1980年至1989年EAPC死亡率为-6.2% (95% CI为-6.4至-5.9)，1989年至2000年为-2.3% (95% CI为-2.6至-2.1)，2000年至2002年为-0.5% （95% CI为-3.7至2.9）。在55岁的女性和男性中，与早期相比，近年来冠心病死亡率的估计年百分比下降速度加快。结论青壮年冠心病的死亡率可以作为一个前哨事件。冠心病几个危险因素的不利趋势可能解释了观察到的死亡率。
Objectives The objective of our study was to examine age-specific mortality rates from coronary heart disease (CHD), particularly those among younger adults.Background Trends for obesity, diabetes, blood pressure, and metabolic syndrome among young adults raise concerns about the mortality rates from CHD in this group.Methods We used mortality data from 1980 to 2002 to calculate age-specific mortality rates from CHD for U.S. adults age 35 years.Results Overall, the age-adjusted mortality rate decreased by 52% in men and 49% in women. Among women age 35 to 54 years, the estimated annual percentage change (EAPC) in mortality was -5.4% (95% confidence interval [Cl] -5.8 to -4.9) from 1980 until 1989, -1.2% (95% CI -1.6 to -0.8) from 1989 until 2000, and 1.5% (95% CI -3.4 to 6.6) from 2000 until 2002. Among men age 35 to 54 years, the EAPC in mortality was -6.2% (95% CI -6.4 to -5.9) from 1980 until 1989, -2.3% (95% CI -2.6 to -2.1) from 1989 until 2000, and -0.5% (95% CI -3.7 to 2.9) from 2000 until 2002. Among women and men age >= 55 years, the estimated annual percentage decrease in mortality from CHD accelerated in more recent years compared with earlier periods.Conclusions The mortality rates for CHD among younger adults may serve as a sentinel event. Unfavorable trends in several risk factors for CHD provide a likely explanation for the observed mortality rates.