The effect of movement frequency on cerebral activation: a positron emission tomography study
The effect of movement frequency on cerebral activation: a positron emission tomography study
复制标题
DOI：
10.1016/s0022-510x(97)00145-7
复制
发表时间：
1997-10-22
影响因子：
4.4
通讯作者：
Brooks, DJ
中科院分区：
文献类型：
--
作者：
Jenkins, IH;Passingham, RE;Brooks, DJ
在正电子发射断层扫描（PET）研究中，运动区激活的性能频率的影响的知识是至关重要的实验中，性能是一个变量的解释。我们研究了这种影响，在六个正常的右利手志愿者使用（H2O）-O-15 PET测量局部脑血流量（rCBF）。受试者在休息时进行扫描，同时用右手以不同的频率在自由选择的方向上执行操纵杆运动。在对侧感觉运动皮层、双侧外侧运动前皮层、后辅助运动区（SMA）和同侧小脑半球和小脑蚓部，rCBF表现出显著的频率依赖性增加。纹状体和右背侧前额叶皮层也被激活的操纵杆运动相比，休息，但在这些地区的激活幅度是独立的运动频率。结果表明，初级运动皮质、后部SMA、外侧运动前皮质和小脑参与决定运动的基本参数。这些区域的频率依赖性激活表明与运动相关的阶段性活动。相反，背侧前额叶皮层和纹状体的激活不是频率依赖性的。这可能反映了在任务期间这些区域的连续活动而不是阶段性活动，并表明它们的作用不仅仅与运动执行有关，而是在此自由选择操纵杆任务期间的更高水平。(C)1997年Elsevier Science B.V.
Knowledge of the effect of performance frequency on activation of motor areas in positron emission tomography (PET) studies is crucial to the interpretation of experiments in which performance is a variable. We studied this effect in six normal right-handed volunteers using (H2O)-O-15 PET to measure regional cerebral blood flow (rCBF). Subjects were scanned at rest and while executing joystick movements with the right hand in freely chosen directions at different frequencies. Significant frequency dependent increases in rCBF were demonstrated in contralateral sensorimotor cortex, lateral premotor cortex bilaterally, posterior supplementary motor area (SMA), and ipsilateral cerebellar hemisphere and vermis. The striatum and the right dorsal prefrontal cortex were also activated by joystick movement compared with rest, but the magnitude of activation found in these areas was independent of the frequency of movement. The results suggest that primary motor cortex, posterior SMA, lateral premotor cortex and cerebellum are involved in determining the basic parameters of movement. Frequency dependent activation in these areas suggests phasic activity related to movement. In contrast, activation of the dorsal prefrontal cortex and the striatum is not frequency dependent. This may reflect continuous rather than phasic activity in these areas during the task and suggests their role is not simply related to movement execution but higher level during this free selection joystick task. (C) 1997 Elsevier Science B.V.