Investigating the Joint Effect of Allostatic Load among Lesbian, Gay, and Bisexual Adults with Risk of Cancer Mortality.
Investigating the Joint Effect of Allostatic Load among Lesbian, Gay, and Bisexual Adults with Risk of Cancer Mortality.
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DOI：
10.3390/ijerph20126120
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发表时间：
2023-06-13
影响因子：
--
通讯作者：
Adsul, Prajakta
中科院分区：
文献类型：
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作者：
Moore, Justin Xavier;Andrzejak, Sydney Elizabeth;Casanova, Tracy;Langston, Marvin E;Estvold, Soren;Adsul, Prajakta
性少数群体（SM）有较高的慢性生理压力所示的非稳态负荷（AL），这可能是部分解释了一贯的歧视性做法的经验。这是第一个研究SM状态和AL对癌症死亡长期风险的联合影响的研究之一。研究人员使用2001年至2010年的国家健康和营养检查调查（NHANES）对12，470名参与者进行了回顾性分析，并将其与截至2019年12月31日的国家死亡指数联系起来。考克斯比例风险模型估计了SM组之间癌症死亡的校正风险比（aHR）（报告为男同性恋、女同性恋、双性恋或有同性性伴侣的人）状态和AL。患有高AL的SM成年人（n = 326）的癌症死亡风险增加2倍（aHR：2.55，95% CI：1.40-4.65）与低AL的直/异性恋成年人（n = 6674）相比。在高AL患者中，SM（n = 326）的癌症死亡风险是高AL直/异性恋成人（n = 4957）的2倍（aHR：2.26，95% CI：1.33-3.84）。高AL的SM具有增加的癌症死亡风险。这些发现强调了重要的意义，促进重点议程的癌症预防战略，减少慢性压力的SM成年人。
Sexual minorities (SM) have higher chronic physiologic stress as indicated by allostatic load (AL), which may be explained in part by consistent experiences of discriminatory practices. This is one of the first studies to examine the joint effects of SM status and AL on the association with long-term risk for cancer death. Retrospective analyses were conducted on 12,470 participants using National Health and Nutrition Examination Survey (NHANES) from years 2001 through 2010 linked with the National Death Index through December 31, 2019. Cox proportional hazards models estimated adjusted hazard ratios (aHRs) of cancer deaths between groups of SM (those reporting as gay, lesbian, bisexual, or having same-sex sexual partners) status and AL. SM adults living with high AL (n = 326) had a 2-fold increased risk of cancer death (aHR: 2.55, 95% CI: 1.40–4.65) when compared to straight/heterosexual adults living with low AL (n = 6674). Among those living with high AL, SM (n = 326) had a 2-fold increased risk of cancer death (aHR: 2.26, 95% CI: 1.33–3.84) when compared to straight/heterosexual adults with high AL (n = 4957). SM with high AL have an increased risk of cancer mortality. These findings highlight important implications for promoting a focused agenda on cancer prevention with strategies that reduce chronic stress for SM adults.