Apoptosis pattern in human endometrium in women with pelvic endometriosis
Apoptosis pattern in human endometrium in women with pelvic endometriosis
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DOI：
10.1016/j.ejogrb.2006.04.008
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发表时间：
2007-05-01
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影响因子：
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通讯作者：
Szymanowski, Krzysztof
中科院分区：
文献类型：
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作者：
Szymanowski, Krzysztof
目的：在本研究中，我们的目的是描述子宫内膜异位症患者在位子宫内膜的细胞凋亡模式，以评估其作为子宫内膜异位症早期标志物的价值，并试图回答子宫内膜异位症是否由在位子宫内膜内的变化引起，或者子宫内膜异位病变是否改变了在位子宫内膜的特征。这项研究是在生殖科治疗的125名妇女中进行的。52例患者诊断为腹膜子宫内膜异位症（I-0-23; II 0 -29）。73例腹腔镜检查未发现病灶的患者作为对照组。排卵后7-9天取子宫内膜活检进行凋亡评估（TUNEL）和常规组织学检查。结果：子宫内膜异位症患者在位内膜的凋亡指数低于非子宫内膜异位症患者。在子宫内膜腺体中，有和没有子宫内膜异位症的妇女的凋亡指数分别为2.94 +/- 1.66和5.23 +/- 2.06（p < 0.01）。子宫内膜间质细胞凋亡指数在子宫内膜异位症组为2.04 ± 1.72，在对照组为4.12 ± 1.62（p < 0.01）。结论：子宫内膜异位症患者在位内膜的不同特性可能是腹膜内异症的一个致病因素。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
Objective: In the present study we aimed to describe apoptosis patterns in eutopic endometrium in women suffering from endometriosis in order to assess its value as a marker of early forms of endometriosis, and also to try to answer whether endometriosis is caused by changes within the eutopic endometrium or whether endometriotic lesions change the characteristics of eutopic endometrium.Study design: The study was performed on 125 women treated in Division of Reproduction. In 52 patients peritoneal endometriosis was diagnosed (I-0-23; II0-29). Seventy-three patients in whom no endometriotic foci could be found at laparoscopy were qualified as the control group. Endometrial biopsy 7-9 days after ovulation was taken for assessment of apoptosis (TUNEL) and routine histology.Results: Apoptosis indices in the eutopic endometrium of women with endometriosis were lower compared to women without endometriosis. In the endometrial glands apoptosis indices were 2.94 +/- 1.66 versus 5.23 +/- 2.06 (p < 0.01) in the group of women with and without endometriosis, respectively. In the endometrial stroma apoptosis indices were estimated at 2.04 +/- 1.72 in women with endometriosis and 4.12 +/- 1.62 in the control group (p < 0.01).Conclusions: The observed changes could support the hypothesis of the different properties of eutopic endometrium in endometriotic women as a causing factor of peritoneal endometriosis. (c) 2006 Elsevier Ireland Ltd. All rights reserved.