Construction of brain atlases based on a multi-center MRI dataset of 2020 Chinese adults
Construction of brain atlases based on a multi-center MRI dataset of 2020 Chinese adults
复制标题
基于2020年中国成年人多中心MRI数据集的脑图谱构建
DOI：
10.1038/srep18216
复制
发表时间：
2015-12-18
影响因子：
4.6
通讯作者：
Li, Kuncheng
中科院分区：
文献类型：
--
作者：
Liang, Peipeng;Shi, Lin;Li, Kuncheng
尽管不同来源(如年龄和种族)的人群的大脑存在已知的形态差异(如大脑形状和大小)，但对中国人的脑图谱研究较少。在本研究中，我们基于2020名中国成年人(18-76岁)的多中心高质量磁共振成像(MRI)数据集，开发了一套统计脑图谱。我们以5年为间隔，从20岁到75岁，共建立了12个中国人的脑图谱。进一步定义了新的中国脑标准空间、坐标和脑区标签。新的中文脑图谱在脑配准和分割中得到了验证。结果表明，与MNI152模板相比，本文提出的中文图谱具有更高的海马区分割准确率和相对较小的配准变形。这些结果表明，特定人群的时变脑图谱可能更适合于涉及中国人群的研究。
Despite the known morphological differences (e.g., brain shape and size) in the brains of populations of different origins (e.g., age and race), the Chinese brain atlas is less studied. In the current study, we developed a statistical brain atlas based on a multi-center high quality magnetic resonance imaging (MRI) dataset of 2020 Chinese adults (18–76 years old). We constructed 12 Chinese brain atlas from the age 20 year to the age 75 at a 5 years interval. New Chinese brain standard space, coordinates and brain area labels were further defined. The new Chinese brain atlas was validated in brain registration and segmentation. It was found that, as contrast to the MNI152 template, the proposed Chinese atlas showed higher accuracy in hippocampus segmentation and relatively smaller shape deformations during registration. These results indicate that a population-specific time varying brain atlas may be more appropriate for studies involving Chinese populations.