Accuracy of potential diagnostic indicators for coeliac disease: a systematic review protocol.
Accuracy of potential diagnostic indicators for coeliac disease: a systematic review protocol.
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DOI：
10.1136/bmjopen-2020-038994
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发表时间：
2020-10-05
期刊：
影响因子：
2.9
通讯作者：
Whiting P
中科院分区：
文献类型：
--
作者：
Elwenspoek MMC;Jackson J;Dawson S;Everitt H;Gillett P;Hay AD;Jones HE;Lane DL;Mallett S;Robins G;Sheppard AL;Stubbs J;Thom H;Watson J;Whiting P
乳糜泻（CD）是一种由麸质引发的全身性免疫介导的疾病，发生在遗传易感个体中。CD的诊断使用血清学测试和小肠内镜活检的组合。然而，由于非特异性症状和异质性临床表现，诊断CD是具有挑战性的。通过改进病例发现策略早期发现CD可以改善对无麸质饮食的反应，提高患者的生活质量，并可能降低并发症的风险。然而，对于哪些群体可以从积极的病例调查中受益，缺乏共识。我们将进行一项系统评价，以确定成人和儿童CD诊断指标（如症状和风险因素）的准确性，从而帮助确定应提供CD检测的患者。检索MEDLINE、Embase、科克伦图书馆和Web of Science，检索时间为1997年至2020年。筛选将一式两份进行。数据提取将由一名审查员进行，并由第二名审查员进行检查。分歧将通过讨论或转介给第三位评审员来解决。我们将对确定的预测模型进行叙述性总结。可提取或重建2×2数据的研究将被视为诊断准确性研究，即诊断指标为指标试验，CD血清学和/或活检为参考标准。对于每个诊断指标，我们将进行双变量随机效应荟萃分析的敏感性和特异性。研究结果将在同行评审期刊、学术和公共演讲以及社交媒体上进行报道。我们将召集一个执行小组，就加强传播的最佳战略提出建议。我们将与英国腹腔科讨论研究结果，以帮助向患者传播。伦理批准不适用，因为这是一项系统性综述，不涉及研究参与者。CRD 42020170766。
Coeliac disease (CD) is a systemic immune-mediated disorder triggered by gluten in genetically predisposed individuals. CD is diagnosed using a combination of serology tests and endoscopic biopsy of the small intestine. However, because of non-specific symptoms and heterogeneous clinical presentation, diagnosing CD is challenging. Early detection of CD through improved case-finding strategies can improve the response to a gluten-free diet, patients’ quality of life and potentially reduce the risk of complications. However, there is a lack of consensus in which groups may benefit from active case-finding. We will perform a systematic review to determine the accuracy of diagnostic indicators (such as symptoms and risk factors) for CD in adults and children, and thus can help identify patients who should be offered CD testing. MEDLINE, Embase, Cochrane Library and Web of Science will be searched from 1997 until 2020. Screening will be performed in duplicate. Data extraction will be performed by one and checked by a second reviewer. Disagreements will be resolved through discussion or referral to a third reviewer. We will produce a narrative summary of identified prediction models. Studies, where 2×2 data can be extracted or reconstructed, will be treated as diagnostic accuracy studies, that is, the diagnostic indicators are the index tests and CD serology and/or biopsy is the reference standard. For each diagnostic indicator, we will perform a bivariate random-effects meta-analysis of the sensitivity and specificity. Results will be reported in peer-reviewed journals, academic and public presentations and social media. We will convene an implementation panel to advise on the optimum strategy for enhanced dissemination. We will discuss findings with Coeliac UK to help with dissemination to patients. Ethical approval is not applicable, as this is a systematic review and no research participants will be involved. CRD42020170766.
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DOI：
10.1136/bmj.b2535
发表时间：
2009-07-21
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
PRISMA Group
DOI：
10.1097/mpg.0b013e31821a23d0
发表时间：
2012-01-01
影响因子：
2.9
作者：
Husby, S.;Koletzko, S.;Zimmer, K. P.
通讯作者：
Zimmer, K. P.
影响因子：
10.3
作者：
Elfstrom, Peter;Granath, Fredrik;Ludvigsson, Jonas F.
通讯作者：
Ludvigsson, Jonas F.
影响因子：
24.5
作者：
Ludvigsson, Jonas F.;Bai, Julio C.;Sanders, David S.
通讯作者：
Sanders, David S.
影响因子：
105.7
作者：
Hin, H;Bird, G;Jewell, D
通讯作者：
Jewell, D