The link of C4B null allele to autism and to a family history of autoimmunity in Egyptian autistic children
The link of C4B null allele to autism and to a family history of autoimmunity in Egyptian autistic children
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DOI：
10.1016/j.jneuroim.2010.03.025
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发表时间：
2010-06-01
影响因子：
3.3
通讯作者：
Shehab, Abeer A.
中科院分区：
文献类型：
--
作者：
Mostafa, Gehan A.;Shehab, Abeer A.
自身免疫可能在自闭症中起作用，其背后的原因尚不清楚。一些自身免疫性疾病与补体(C) 4B空等位基因之间存在关联。我们的目的是研究C4B空等位基因与自闭症的关系。此外，我们是第一个调查该等位基因与自闭症儿童自身免疫性疾病家族史之间的关系。因此，我们通过实时荧光定量PCR检测了80例自闭症患者和80例健康配对儿童的C4B空等位基因的频率。自闭症患者C4B空等位基因频率（37.5%）显著高于健康对照组（8.75%），P < 0.05
The reason behind the initiation of autoimmunity, which may have a role in autism, is not well understood. There is an association between some autoimmune disorders and complement (C) 4B null allele. We aimed to study the association between C4B null allele and autism. In addition, we are the first to investigate the association between this allele and a family history of autoimmune diseases in autistic children. Therefore, we examined the frequency of C4B null allele, by quantitative real-time PCR, in 80 autistic patients and 80 healthy matched-children. The frequency of C4B null allele was significantly higher in autistic patients (37.5%) than healthy controls (8.75%), P