COMPARISON OF RADIOISOTOPE METHODS FOR THE MEASUREMENT OF PHOSPHATE ABSORPTION IN NORMAL SUBJECTS AND IN PATIENTS WITH CHRONIC-RENAL-FAILURE
COMPARISON OF RADIOISOTOPE METHODS FOR THE MEASUREMENT OF PHOSPHATE ABSORPTION IN NORMAL SUBJECTS AND IN PATIENTS WITH CHRONIC-RENAL-FAILURE
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DOI：
10.1042/cs0600055
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发表时间：
1981-01-01
期刊：
影响因子：
6
通讯作者：
MOORHEAD, JF
中科院分区：
文献类型：
--
作者：
FARRINGTON, K;MOHAMMED, MN;MOORHEAD, JF
1.用双同位素技术测定了正常人、慢性肾功能衰竭患者和移植后患者的肠道磷酸盐吸收，包括口服~(32)P和静脉注射~(33)P，然后进行去卷积分析。这项技术表明，肠道磷酸盐吸收有两个部分：最初的快速阶段，在3h内完成，以及较慢的较长时间阶段，持续到7 1/2H.在慢性肾功能衰竭和移植患者中已经证实了磷酸盐吸收不良，这是由于最初的快速吸收相受损所致。将去卷积分析得到的结果与仅通过分析~(32)P放射性曲线获得的磷酸盐吸收的其他估计进行了比较。就最大磷酸盐吸收速率和累积磷酸盐吸收百分比而言，经细胞外液体积校正后的每小时吸收速率分数和60min时的血浆~(32)P放射性活度与去卷积分析得到的结果最接近。
1. Intestinal phosphate absorption was measured in normal subjects, in patients with chronic renal failure, and in post-transplant patients, by a double isotope technique involving oral administration of32P and simultaneous intravenous injection of33P with subsequent deconvolution analysis.2. By this technique intestinal phosphate absorption has been shown to have two components: an initial rapid phase, which is completed by 3 h, and a slower more prolonged phase, which continues beyond 7 1/2 h.3. Phosphate malabsorption has been demonstrated in chronic renal failure and transplant patients, which is accounted for by impairment of the initial rapid phase of absorption.4. Results obtained by deconvolution analysis have been compared with other estimates of phosphate absorption obtained from analysis of32P radioactivity curves alone.5. The fractional hourly rate of absorption and the plasma32P radioactivity at 60 min corrected for extracellular fluid volume provided the best approximations to the result obtained by deconvolution analysis, with respect to both the maximal rate of phosphate absorption and cumulative percentage phosphate absorption.