Human memory strength is predicted by theta-frequency phase-locking of single neurons
Human memory strength is predicted by theta-frequency phase-locking of single neurons
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DOI：
10.1038/nature08860
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发表时间：
2010-04-08
期刊：
影响因子：
64.8
通讯作者：
Schuman, Erin M.
中科院分区：
文献类型：
--
作者：
Rutishauser, Ueli;Ross, Ian B.;Schuman, Erin M.
从新的经验中学习是中枢神经系统的一项主要任务。在哺乳动物中，内侧颞叶对于这种快速学习形式至关重要（1）。通过可塑性对突触和神经元回路的修饰被认为是记忆形成的基础（2）。突触可塑性的诱导受到神经元群体之间协调的动作电位时序的支持（3）。神经群的这种协调活动可以引起不同频率的振荡，记录在局部场电位中。θ频率范围（3-8 Hz）的脑振荡通常与突触可塑性以及行为记忆的有利诱导有关（4）。在这里，我们报告的活动记录在一起的单个神经元的局部场电位在人类从事的学习任务。我们表明，成功的记忆形成在人类的预测与当地θ振荡的尖峰时间的紧密协调。更多的刻板尖峰预示着更好的记忆力，正如受试者报告的更高的检索信心所示。这些发现提供了许多记忆调节行为和可塑性回路机制对θ振荡的已知调制之间的联系。
Learning from novel experiences is a major task of the central nervous system. In mammals, the medial temporal lobe is crucial for this rapid form of learning(1). The modification of synapses and neuronal circuits through plasticity is thought to underlie memory formation(2). The induction of synaptic plasticity is favoured by coordinated action-potential timing across populations of neurons(3). Such coordinated activity of neural populations can give rise to oscillations of different frequencies, recorded in local field potentials. Brain oscillations in the theta frequency range (3-8 Hz) are often associated with the favourable induction of synaptic plasticity as well as behavioural memory(4). Here we report the activity of single neurons recorded together with the local field potential in humans engaged in a learning task. We show that successful memory formation in humans is predicted by a tight coordination of spike timing with the local theta oscillation. More stereotyped spiking predicts better memory, as indicated by higher retrieval confidence reported by subjects. These findings provide a link between the known modulation of theta oscillations by many memory-modulating behaviours and circuit mechanisms of plasticity.