Focal glomerulosclerosis in patients with unilateral nephrectomy.
Focal glomerulosclerosis in patients with unilateral nephrectomy.
复制标题
单侧肾切除术患者的局灶性肾小球硬化。
作者：
P. Zucchelli;L. Cagnoli;S. Casanova;U. Donini;S. Pasquali
为了研究蛋白尿和局灶性肾小球硬化症（FSG）是否可能在人类以及实验模型中发生，我们对24例因单侧肾脏疾病行肾切除术的患者进行了回顾性研究。所有患者均未出现全身性疾病体征。Alport综合征、原发性高血压、反流性肾病及其他静脉肾盂造影异常。在第一次观察时，7名患者有病理性蛋白尿（第1组），而17名患者的蛋白排泄正常（第2组）。第1组的所有患者和第2组的17例患者中仅4例为男性。两组之间没有发现其他显著差异。蛋白尿患者肾切除术时的中位年龄为22.3岁，平均12.2年后出现蛋白尿。在4例患者中进行了肾活检，显示出恒定的FSG模式。平均随访7.3年后，所有患者的蛋白尿保持不变，肾功能保持良好。总之，我们的系列研究表明，在人类中，由于肾切除术，蛋白尿和FSG也可能出现在孤立肾中。这种肾小球损害可能是由于肾小球超载与其他不明因素的关系。
To investigate whether proteinuria and focal glomerulosclerosis (FSG) might develop in humans as well as in experimental models following a reduction in renal mass, we performed a retrospective study of 24 patients previously nephrectomized for unilateral renal disease. None of the patients presented signs of systemic diseases. Alport syndrome, essential hypertension, reflux nephropathy, and other abnormalities on intravenous pyelography. At the time of the first observation seven patients had pathological proteinuria (group 1) while 17 presented a normal protein excretion (group 2). All patients in group 1 and only 4 of 17 in group 2 were male. No other significant differences were found between the two groups. The median age at nephrectomy of the proteinuric patients was 22.3 years, and proteinuria developed after a mean period of 12.2 years. A renal biopsy was performed in four patients and showed a constant pattern of FSG. After a mean follow-up period of 7.3 years from the onset, proteinuria remains unchanged and renal function is well preserved in all the patients. In conclusion our series suggests that also in humans proteinuria and FSG might appear in solitary kidneys due to nephrectomy. This glomerular damage may result from the association of glomerular overload with other unidentified factors.
影响因子：
158.5
作者：
BRENNER, BM;MEYER, TW;HOSTETTER, TH
通讯作者：
HOSTETTER, TH
肾脏质量极度消融后，肾小球通透性发生改变，进行性硬化。
影响因子：
19.6
作者：
Olson,JL;Hostetter,TH;Rennke,HG;Brenner,BM;Venkatachalam,MA
通讯作者：
Venkatachalam,MA