Relationship Between Retinol-Binding Protein-4/Adiponectin and Leptin/Adiponectin Ratios with Insulin Resistance and Inflammation
Relationship Between Retinol-Binding Protein-4/Adiponectin and Leptin/Adiponectin Ratios with Insulin Resistance and Inflammation
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DOI：
10.1089/met.2014.0013
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发表时间：
2014-05-01
影响因子：
2.1
通讯作者：
Smith, Gerred
中科院分区：
文献类型：
--
作者：
Jialal, Ishwarlal;Adams-Huet, Beverley;Smith, Gerred
背景：有大量数据支持脂肪因子在肥胖和代谢综合征中的作用。胰岛素抵抗和低度炎症对于这两种疾病的发生至关重要。尽管数据表明瘦素/脂联素比率与胰岛素抵抗相关并可预测心血管疾病 (CVD)，但关于视黄醇结合蛋白 4 (RBP4)/脂联素比率与胰岛素抵抗和炎症之间关系的数据很少。我们测试了这两个比率与胰岛素抵抗和炎症指标的关系。方法：在 72 名个体中，包括对照组和代谢综合征患者，我们计算了胰岛素抵抗稳态模型评估 (HOMA-IR)，并测定了高敏 C 反应蛋白 (hsCRP) 和脂肪因子、脂联素、瘦素和 RBP4。结果：尽管瘦素/脂联素和 RBP4/脂联素比率与 HOMA-IR 均不相关，但两者均与炎症原型生物标志物 hsCRP 显着相关。同样，在调整肥胖后的代谢综合征患者中，只有 RBP4/脂联素比率显着增加。结论：因此，虽然瘦素/脂联素和 RBP4/脂联素比值均与炎症相关，但只有 RBP4/脂联素比值在代谢综合征中显着升高，并且更有助于预测 CVD，特别是在代谢综合征中。
Background: There is much data supporting a role for adipokines in both obesity and metabolic syndrome. Insulin resistance and low-grade inflammation are crucial in the genesis of both disorders. Although data suggest that the ratio of leptin/adiponectin correlates with insulin resistance and predicts cardiovascular disease (CVD), there is scanty data on the relationship between the retinol-binding protein-4 (RBP4)/adiponectin ratio with insulin resistance and inflammation. We tested the relationship of both these ratios with measures of insulin resistance and inflammation. Methods: In 72 individuals, including controls and patients with metabolic syndrome, we calculated the homeostasis model assessment of insulin resistance (HOMA-IR) and assayed high-sensitivity C-reactive protein (hsCRP) and the adipokines, adiponectin, leptin, and RBP4. Results: Whereas both the leptin/adiponectin and RBP4/adiponectin ratios did not correlate with HOMA-IR, both correlated significantly with the prototypic biomarker of inflammation, hsCRP. Also in patients with metabolic syndrome following adjustment for adiposity, only the RBP4/adiponectin ratio was significantly increased. Conclusions: Hence it appears that whereas both the leptin/adiponectin and RBP4/adiponectin ratios correlate with inflammation, only the RBP4/adiponectin ratio was significantly increased in metabolic syndrome and would be more useful to predict CVD, especially in metabolic syndrome.