Recombinant murine interferon-gamma inhibits the fusion of mouse alveolar macrophages in vitro but stimulates the formation of osteoclastlike cells on implanted syngeneic bone particles in mice in vivo.
Recombinant murine interferon-gamma inhibits the fusion of mouse alveolar macrophages in vitro but stimulates the formation of osteoclastlike cells on implanted syngeneic bone particles in mice in vivo.
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重组鼠干扰素-γ在体外抑制小鼠肺泡巨噬细胞的融合，但在体内刺激小鼠植入的同源骨颗粒上破骨细胞样细胞的形成。
DOI：
10.1002/jbmr.5650050613
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Shepard,MH
中科院分区：
文献类型：
--
作者：
Vignery,A;Niven-Fairchild,T;Shepard,MH
破骨细胞是起源于单核前体细胞融合的多核细胞，负责骨吸收。来自体外研究的间接证据表明，IFN-γ和TNF-α分别抑制和刺激骨吸收，但关于IFN-γ对巨噬细胞多核化的影响，文献中出现了相互矛盾的结果。使用高度敏感的模型系统，目前的工作表明，在小鼠中，rMuIFN-γ在体外抑制肺泡巨噬细胞的融合，但在体内增加植入的同源骨颗粒上的破骨细胞样细胞的数量。尽管rMuTNF-α在两种系统中均不能刺激巨噬细胞多核化，但用rMuIFN-γ治疗植入动物似乎可以限制炎症反应并有利于组织修复。
Osteoclasts are multinucleated cells that originate from the fusion of mononuclear precursors and are responsible for bone resorption. Indirect evidence from in vitro studies suggests that IFN‐γ and TNF‐α inhibit and stimulate bone resorption, respectively, but contradictory results have emerged from the literature regarding the effects of IFN‐γ on macrophage multinucleation. Using highly sensitive model systems, the present work demonstrates that, in mice, rMuIFN‐γ inhibits the fusion of alveolar macrophages in vitro but augments the number of osteoclastlike cells on implanted syngeneic bone particles in vivo. Although rMuTNF‐α fails to stimulate macrophage multinucleation in either system, treatment of implanted animals with rMuIFN‐γ appears to limit the inflammatory reaction and favor tissue repair.