A Chronically Implantable Neural Coprocessor for Investigating the Treatment of Neurological Disorders
A Chronically Implantable Neural Coprocessor for Investigating the Treatment of Neurological Disorders
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DOI：
10.1109/tbcas.2018.2880148
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发表时间：
2018-12-01
影响因子：
5.1
通讯作者：
Denison, Timothy
中科院分区：
文献类型：
--
作者：
Stanslaski, Scott;Herron, Jeffrey;Denison, Timothy
开发新的工具来更好地理解神经系统疾病，目标是更有效地治疗它们，是生物电子医学研究的一个活跃领域。鉴于对神经调节机制和如何配置系统以获得最佳临床结果的不断发展的理解，未来的工具必须是灵活和可配置的。我们描述了一个系统，Summit RC+S“神经协处理器”，它试图将微处理器的能力和灵活性引入嵌入神经系统的假体。本文介绍了Summit RC+S系统的更新系统架构，双向神经接口所需的五个定制集成电路，支持固件/软件生态系统，以及为人体植入做准备的验证和验证活动。重点放在设计变化的动机与经验，ce标志的Activa PC+S研究工具；具体而言，增强感官刺激性能以改善与神经系统的双向通信，实现可充电技术以延长设备寿命，以及应用mic波段遥测技术进行算法开发和数据管理。该技术在患有自然癫痫的犬类的慢性治疗范例中得到验证，包括在家庭环境中自由走动，这代表了未来人类协议的典型用例。
Developing new tools to better understand disorders of the nervous system, with a goal to more effectively treat them, is an active area of bioelectronic medicine research. Future tools must be flexible and configurable, given the evolving understanding of both neuromodulation mechanisms and how to configure a system for optimal clinical outcomes. We describe a system, the Summit RC+S "neural coprocessor," that attempts to bring the capability and flexibility of a microprocessor to a prosthesis embedded within the nervous system. This paper describes the updated system architecture for the Summit RC+S system, the five custom integrated circuits required for bi-directional neural interfacing, the supporting firmware/software ecosystem, and the verification and validation activities to prepare for human implantation. Emphasis is placed on design changes motivated by experience with the CE-marked Activa PC+S research tool; specifically, enhancement of sense-stim performance for improved bi-directional communication to the nervous system, implementation of rechargeable technology to extend device longevity, and application of MICS-band telemetry for algorithm development and data management. The technology was validated in a chronic treatment paradigm for canines with naturally occurring epilepsy, including free ambulation in the home environment, which represents a typical use case for future human protocols.