MT-III, A BRAIN-SPECIFIC MEMBER OF THE METALLOTHIONEIN GENE FAMILY
MT-III, A BRAIN-SPECIFIC MEMBER OF THE METALLOTHIONEIN GENE FAMILY
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DOI：
10.1073/pnas.89.14.6333
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发表时间：
1992-07-15
影响因子：
11.1
通讯作者：
DURNAM, DM
中科院分区：
文献类型：
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作者：
PALMITER, RD;FINDLEY, SD;DURNAM, DM
金属硫蛋白(MT)基因家族的第三个成员，被命名为MT-III，凭借其与人类蛋白质的同源性而被克隆，该蛋白质先前被证明在培养中抑制神经元存活，并在阿尔茨海默病患者的大脑中缺乏。人类和小鼠MT-III相对于所有其他已知的哺乳动物MT-III有两个插入：在第四个氨基酸之后有一个苏氨酸，在羧基末端附近有一个由六个氨基酸组成的区块。编码MT-III的基因在大小和外显子/内含子组织上与所有其他哺乳动物的MT基因相似。MT-III基因与人类16号染色体和小鼠8号染色体上的其他功能MT基因紧密连锁。小鼠MT-III基因的表达似乎仅限于大脑；此外，它对体内的锌、镉、地塞米松或细菌内毒素没有反应，从而将MT-III与其他已知的MT-III区分开来。
A third member of the metallothionein (MT) gene family, designated MT-III, was cloned by virtue of its homology to a human protein that was shown previously to inhibit neuronal survival in culture and to be deficient in the brains of people with Alzheimer disease. Human and mouse MT-IIIs have two insertions relative to all other known mammalian MTs: a threonine after the fourth amino acid and a block of six amino acids near the carboxyl terminus. The genes encoding MT-III resemble all other mammalian MT genes in their small size and exon/intron organization. The MT-III genes are closely linked to the other functional MT genes on human chromosome 16 and mouse chromosome 8. Mouse MT-III gene expression appears to be restricted to brain; in addition, it fails to respond to zinc, cadmium, dexamethasone, or bacterial endotoxin in vivo, thereby distinguishing MT-III from other known MTs.