AN OBSERVATIONAL METHOD FOR QUANTIFYING THE BEHAVIORAL-EFFECTS OF DOPAMINE AGONISTS - CONTRASTING EFFECTS OF D-AMPHETAMINE AND APOMORPHINE
AN OBSERVATIONAL METHOD FOR QUANTIFYING THE BEHAVIORAL-EFFECTS OF DOPAMINE AGONISTS - CONTRASTING EFFECTS OF D-AMPHETAMINE AND APOMORPHINE
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DOI：
10.1007/bf00433091
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发表时间：
1980-01-01
影响因子：
3.4
通讯作者：
IVERSEN, SD
中科院分区：
文献类型：
--
作者：
FRAY, PJ;SAHAKIAN, BJ;IVERSEN, SD
通过比较 d-安非他明和阿扑吗啡对大鼠的影响，描述和说明了一种测量和分析多巴胺激动剂行为影响的新方法。 d-安非他明（0-15 mg/kg，腹膜内注射）会在运动、站立和嗅觉等反应中产生显着的剂量和时间依赖性变化，但在舔或啃咬方面不会产生变化。阿朴吗啡（0-5 mg/kg s.c.）显着增加了舔舐和啃咬、运动和嗅觉的能力，但对饲养的能力没有变化。将结果与通过其他方法（例如光电管光束中断或刻板评级量表）获得的结果进行比较进行讨论，并且可能对于阐明前脑多巴胺投射的功能具有重要意义。
A novel means of measuring and analyzing behavioral effects of dopamine agonists is described and illustrated by a comparison of the effects of d-amphetamine and apomorphine in the rat. d-Amphetamine (0-15 mg/kg i.p.) produced significant dose- and time-dependent changes in responses such as locomotion, rearing and sniffing, but not in licking or gnawing. Apomorphine (0-5 mg/kg s.c.) produced significant increases in licking and gnawing, and in locomotion and sniffing, but no changes in rearing. The results are discussed in comparison with those obtained by other methods, such as photocell beam interruptions or stereotypy rating scales and may be of importance in elucidating the functions of the forebrain dopamine projections.