Analysis of cartilage-polydioxanone foil composite grafts.
Analysis of cartilage-polydioxanone foil composite grafts.
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软骨-聚二氧环己酮箔复合移植物的分析。
DOI：
10.1055/s-0033-1360593
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Wong,Brian
中科院分区：
文献类型：
--
作者：
Kim,JamesH;Wong,Brian
本研究对软骨-聚二氧环酮（PDS）板复合移植物的力学行为进行了分析研究。本文采用数值方法建立了软骨- pds移植物抗弯刚度的一阶数值模型。抗弯刚度是抗弯曲的一种度量，与结构在受到弯曲力时可能经历的变形量成反比。将软骨- pds移植物建模为单一复合梁。利用伯努利-欧拉梁理论，建立了复合接枝材料理论抗弯刚度的封闭形式方程。通过参数分析，观察了复合材料模型的弯曲性能随PDS箔厚度的变化情况。使用0.15 mm厚PDS的软骨-PDS复合材料的刚度是单独软骨的4倍。0.5 mm厚PDS复合材料的硬度仅为0.15 mm厚PDS复合材料的1.7倍。虽然接枝材料越厚，复合材料的抗弯刚度越高，但复合材料刚度与PDS厚度之间的关系是非线性的。在一个临界点之后，接枝厚度的增加对抗弯刚度的改善逐渐减小。与0.15 mm的PDS箔相比，使用较厚的PDS箔时刚度的小幅增加可能不值得使用较厚的人工移植物带来潜在的并发症（延长异物反应，减少营养物质向软骨扩散）。
This study presents an analytical investigation into the mechanical behavior of a cartilage-polydioxanone (PDS) plate composite grafts. Numerical methods are used to provide a first-order, numerical model of the flexural stiffness of a cartilage-PDS graft. Flexural stiffness is a measure of resistance to bending and is inversely related to the amount of deformation a structure may experience when subjected to bending forces. The cartilage-PDS graft was modeled as a single composite beam. Using Bernoulli-Euler beam theory, a closed form equation for the theoretical flexural stiffness of the composite graft was developed. A parametric analysis was performed to see how the flexural properties of the composite model changed with varying thicknesses of PDS foil. The stiffness of the cartilage-PDS composite using 0.15-mm-thick PDS was four times higher than cartilage alone. The composite with a 0.5-mm-thick PDS graft was only 1.7 times stiffer than the composite with the 0.15-mm-thick PDS graft. Although a thicker graft material will yield higher flexural stiffness for the composite, the relationship between composite stiffness and PDS thickness is nonlinear. After a critical point, increments in graft thickness produce gradually smaller improvements in flexural stiffness. The small increase in stiffness when using the thicker PDS foils versus the 0.15 mm PDS foil may not be worth the potential complications (prolonged foreign body reaction, reduction in nutrient diffusion to cartilage) of using thicker artificial grafts.