Effects of genetic variants on lipid parameters and dyslipidemia in a Chinese population
Effects of genetic variants on lipid parameters and dyslipidemia in a Chinese population
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遗传变异对中国人群血脂参数和血脂异常的影响
DOI：
10.1194/jlr.p007476
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发表时间：
2011-02-01
影响因子：
6.5
通讯作者：
He, Lin
中科院分区：
文献类型：
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作者：
Liu, Yun;Zhou, Daizhan;He, Lin
最近的一些全基因组关联(GWA)研究已经在欧洲人群中确定了几个新的血浆脂质和脂蛋白浓度的遗传决定因素。然而，目前尚不清楚高加索人GWA研究中发现的这些基因座是否也对中国人的血脂和脂蛋白浓度产生同样的影响。我们对中国汉族人群样本(n=4,192)的9个基因座上的10个单核苷酸多态(SNPs)进行了基因分型，并用校正了年龄、性别、糖尿病状况和体重指数的线性回归分析了这些SNPs与代谢性状的关系。三个变异体(rs12654264，P类似于1.7×10(-6)；rs3764261，P类似于7.1×10(-7)；和rs4420638，P类似于1.1×10(-3))显示与总胆固醇有关；四个变异体(rs780094，P类似于1.8×10(-11)；rs17145738，P类似于5.0×10(-7)；rs326，P类似于2.3×10(-6)；和rs439401，P类似于2.2×10(-5))显示出与甘油三酯相关的强有力证据，四个变异体(rs17145738，P类似于1.9×10(-4)；rs326，P类似于9.7×10(-4)；rs1800588，P类似于1.5×10(-7)；以及rs3764261，P类似于4.3×10(-14)显示了与高密度脂蛋白(HDLc)，两个变异体(rs12654264，P类似于2.3×10(-5))相关的强有力证据；4个变异(rs326，P类似于2.8×10(-3)；rs1800588，P类似于6.1×10(-4)；rs3764261，P类似于2.0×10(-3)；以及rs4420638，P类似于9.4×10(-5))显示了与总胆固醇-高密度脂蛋白相关比率的强烈证据。这些SNP对血脂特征和血脂异常产生了强烈的联合作用。我们的发现表明，与欧洲人的代谢特征相关的变异也可能在中国汉族人群中发挥作用。-刘，Y，周，Z.张，Y，宋，D，张，T，Z，陈，Y，孙，D，张，Y，杨，Q.Xing，X.赵，徐华，和L。遗传变异对中国人群血脂参数和血脂异常的影响。J.Lipid Res.2011年。52：354-360。
A number of recent genome-wide association (GWA) studies have identified several novel genetic determinants of plasma lipid and lipoprotein concentrations in European populations. However, it is still unclear whether these loci identified in Caucasian GWA studies also exert the same effect on lipid and lipoprotein concentrations in a Chinese population. We genotyped 10 single-nucleotide polymorphisms (SNPs) in nine loci in a Chinese Han population sample (n = 4,192) and assessed the associations of these SNPs with metabolic traits, using linear regression adjusted for age, gender, diabetes status, and body mass index. Three variants (rs12654264, P similar to 1.7 x 10(-6); rs3764261, P similar to 7.1 x 10(-7); and rs4420638, P similar to 1.1 x 10(-3)) showed strong evidence for association with total cholesterol; four variants (rs780094, P similar to 1.8 x 10(-11); rs17145738, P similar to 5.0 x 10(-7); rs326, P similar to 2.3 x 10(-6); and rs439401, P similar to 2.2 x 10(-5)) showed strong evidence for association with triglycerides, four variants (rs17145738, P similar to 1.9 x 10(-4); rs326, P similar to 9.7 x 10(-4); rs1800588, P similar to 1.5 x 10(-7); and rs3764261, P similar to 4.3 x 10(-14)) showed strong evidence for association with HDL-cholesterol (HDL-C), two variants (rs12654264, P similar to 2.3 x 10(-5); and rs4420638, P similar to 3.6 x 10(-4)) showed strong evidence for association with LDL-C, and four variants (rs326, P similar to 2.8 x 10(-3); rs1800588, P similar to 6.1 x 10(-4); rs3764261, P similar to 2.0 x 10(-3); and rs4420638, P similar to 9.4 x 10(-5)) showed strong evidence for association with total cholesterol-HDL-C-related ratio. These SNPs generated strong combined effects on lipid traits and dyslipidemia. Our findings indicate that the variants that associated with metabolic traits in Europeans may also play a role in a Chinese Han population.-Liu, Y., D. Zhou, Z. Zhang, Y. Song, D. Zhang, T. Zhao, Z. Chen, Y. Sun, D. Zhang, Y. Yang, Q. Xing, X. Zhao, H. Xu, and L. He. Effects of genetic variants on lipid parameters and dyslipidemia in a Chinese population. J. Lipid Res. 2011. 52: 354-360.