Development of photoacoustic imaging technology overlaid on ultrasound imaging and its clinical applications
Development of photoacoustic imaging technology overlaid on ultrasound imaging and its clinical applications
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超声成像叠加光声成像技术发展及其临床应用
DOI：
10.1117/12.2076456
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
Miya Ishihara,Kazuhiro Tsujita,Horiguchi Akio,Kaku Irisawa,Tomohiro Komatsu,Makoto Ayaori,Takeshi Hirasawa,Tadashi Kasamatsu,Kazuhiro Hirota,Hitoshi Tsuda,Katsunori Ikewaki,Tomohiko Asano
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文献类型：
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作者：
Miya Ishihara,Kazuhiro Tsujita,Horiguchi Akio,Kaku Irisawa,Tomohiro Komatsu,Makoto Ayaori,Takeshi Hirasawa,Tadashi Kasamatsu,Kazuhiro Hirota,Hitoshi Tsuda,Katsunori Ikewaki,Tomohiko Asano
目的：光声成像（PAI）使人们能够在不使用造影剂的情况下可视化血红蛋白的分布并获得微血管图。我们研究的目的是开发一种临床应用的PAI系统，该系统与临床超声（US）阵列系统集成，手持PAI探针提供共同注册的PAI和US图像。进行临床研究试验，评价其性能及临床价值的可行性。材料和方法：我们开发了两种类型的手持式PAI探针：一种是线性PAI探针，结合了传统的线性阵列US探针和光学照明，另一种是经直肠超声（TRUS）型PAI探针。经国防医学院医学人体伦理委员会批准，以日本大白兔为实验对象，开展泌尿外科、血管医学临床研究试验。结果：成功获取了兔从毛细血管到标志性动脉的高动态范围血管网络图像，识别出了兔的股静脉、股深静脉和大隐静脉。兔腹股沟的这些主要血管被相互连接的微血管所包围。前列腺癌根治术中监测前列腺周围微血管与神经纤维共定位，其分布与相应的PAI一致。TRUS型PAI探针比单独TRUS更清楚地显示神经血管束（NVB）的位置和范围。结论：该系统具有创新性设计，可以获得PAI、US图像和合并图像，使医生无需任何先验知识或扩展技能即可轻松找到位置，对获得的图像进行分析。我们的初步可行性研究证实PAI可能是一种有用的筛查研究和诊断活检的成像方式。
Purpose: Photoacoustic imaging (PAI) enables one to visualize the distribution of hemoglobin and acquire a map of microvessels without using contrast agents. The purpose of our study is to develop a clinically applicable PAI system integrated with a clinical ultrasound (US) array system with handheld PAI probes providing coregistered PAI and US images. Clinical research trials were performed to evaluate the performance and feasibility of clinical value.Materials and Methods: We developed two types of handheld PAI probes: a linear PAI probe combining a conventional linear-array US probe with optical illumination and a transrectal ultrasonography (TRUS)-type PAI probe. We performed experiments with Japanese white rabbits and conducted clinical research trials of urology and vascular medicine with the approval of the medical human ethics committee of the National Defense Medical College.Results: We successfully acquired high-dynamic-range images of the vascular network ranging from capillaries to landmark arteries and identified the femoral vein, deep femoral vein, and great saphenous vein of rabbits. These major vessels in the rabbits groin are surrounded with microvessels connected to each other. Periprostatic microvessels were monitored during radical prostatectomy for localized prostate cancer and they were colocalized with nerve fibers, and their distribution was consistent with the corresponding PAI. The TRUS-type PAI probe clearly demonstrated the location and extent of the neurovascular bundle (NVB) better than does TRUS alone.Conclusions: The system, which can obtain a PAI, a US image, and a merged image, was innovatively designed so that medical doctors can easily find the location without any prior knowledge or extended skills to analyze the obtained images. Our pilot feasibility study confirms that PAI could be an imaging modality useful in the screening study and diagnostic biopsy.