A Coronary Active Perfusion System for Off-Pump Coronary Artery Bypass: Advantage over Passive Perfusion Regarding the Physiology of the Coronary Artery
A Coronary Active Perfusion System for Off-Pump Coronary Artery Bypass: Advantage over Passive Perfusion Regarding the Physiology of the Coronary Artery
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用于非体外循环冠状动脉搭桥的冠状动脉主动灌注系统：在冠状动脉生理学方面优于被动灌注的优势
DOI：
10.1097/00002480-200211000-00015
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发表时间：
2002
期刊：
影响因子：
4.2
通讯作者：
T. Kanamori
中科院分区：
文献类型：
--
作者：
H. Kamiya;G. Watanabe;Toshio Doi;Taro Saito;Masao Takahashi;S. Tomita;T. Tukioka;T. Kanamori
为了避免非体外循环冠状动脉搭桥术中的心肌缺血，我们开发了一种冠状动脉主动灌注系统（CAPS），该系统通过注射泵系统在心动周期的舒张期向冠状动脉灌注动脉血。我们在此报告的细节和比较CAPS与被动分流电路从股动脉（FA分流），关于冠状动脉的生理。本研究使用了6头猪。在建立CAPS或FA分流灌注后，测量冠状动脉流量和冠状动脉压力。自体冠状动脉、FA分流灌注和CAPS灌注中的冠状动脉流量分别为27.2 ± 3.0、4.1 ± 1.5、12.7 ± 1.2、24.8 ± 1.9、33.3 ± 1.6和42.2 ± 1.9 ml/min，注射泵每搏输出量设置范围为0.1 - 0.4 ml。FA分流灌注和CAPS灌注下的平均冠状动脉压力分别为23.7 ± 4.6、48.8 ± 5.0、61.3 ± 7.5、70.8 ± 5.4和82.3 ± 5.2 mm Hg，卒中设置为0.1 - 0.4 ml。CAPS在安全冠状动脉压力下的冠状动脉血流方面优于FA分流。使用CAPS，非体外循环冠状动脉搭桥术可以安全地进行，而不会出现心肌缺血。
To avoid myocardial ischemia during off-pump coronary artery bypass, we developed a coronary active perfusion system (CAPS) that perfuses arterial blood to the coronary artery at the diastolic phase of the cardiac cycle by a syringe pump system. We report herein the details and compare CAPS with a passive shunt circuit from the femoral artery (FA shunt), regarding the physiology of the coronary artery. Six pigs were used for this study. After CAPS or FA shunt perfusion was established, coronary flow and coronary pressure were measured. The coronary flows in the native coronary artery, FA shunt perfusion, and CAPS perfusion with syringe pump stroke volume settings ranging from 0.1 to 0.4 ml were 27.2 ± 3.0, 4.1 ± 1.5, 12.7 ± 1.2, 24.8 ± 1.9, 33.3 ± 1.6, and 42.2 ± 1.9 ml/min, respectively. Mean coronary pressures under FA shunt perfusion and CAPS perfusion with stroke settings from 0.1 to 0.4 ml were 23.7 ± 4.6, 48.8 ± 5.0, 61.3 ± 7.5, 70.8 ± 5.4, and 82.3 ± 5.2 mm Hg, respectively. CAPS had an advantage over the FA shunt regarding coronary flow with safe coronary pressure. Using CAPS, an off-pump coronary artery bypass can be performed safely without myocardial ischemia.