Deamination of 9-(Hydroxymethylated cycloalkyl)-9H-adenines (Carbocyclic Adenine Nucleosides) by Adenosine Deaminase: Effect of High-Pressure Upon Deamination Rate and Enantioselectivity 1) #
Deamination of 9-(Hydroxymethylated cycloalkyl)-9H-adenines (Carbocyclic Adenine Nucleosides) by Adenosine Deaminase: Effect of High-Pressure Upon Deamination Rate and Enantioselectivity 1) #
复制标题
腺苷脱氨酶对 9-（羟甲基化环烷基）-9H-腺嘌呤（碳环腺嘌呤核苷）的脱氨：高压对脱氨速率和对映选择性的影响 1)
DOI：
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发表时间：
1996
期刊：
影响因子：
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通讯作者：
C. Kaneko
中科院分区：
文献类型：
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作者：
N. Katagiri;Yumiko Ito;T. Shiraishi;T. Maruyama;Y. Sato;C. Kaneko
摘要在高压（400 MPa）下，通过腺苷死亡酶（400 MPa）脱氨酸，将其与大气压下的反应中获得的结果进行了比较。在高压下，制备了三个和五个成员的碳小子核能的反应，在高压下抑制了六个成员的碳纤维核能的反应。在两个条件下，四个成员的核横向率是低的。 Pharm。出价。，1995，43，884。＃本文致力于庆祝北海道大学名誉教授Yoshihisa Mizuno博士75岁生日。
Abstract The deamination of eight kinds of racemic carbocyclic adenine nucleosides by adenosine deaminase under high-pressure (400 MPa) was examined and the result was compared with that obtained from the reaction under atmospheric pressure. The deamination of all carbocyclic nucleosides irrespective to their ring size of carbocycles was facilitated remarkably high-pressure. The reaction of three and five membered carbocyclic nucleosides resulted in the very high enantioselectivity both under high- and atmospheric Plessure whereas the enantioselectivity of six membered carbocyclic nucleosides was suppressed under high-pressure. However, the enantioselectivity of four membered nucleosides was low under both conditions. 1. Part 38 in the series “Synthesis of Nucleosides and Related Compounds”. For Part 37, see Katagiri, N.; Makino, S.; Kaneko, C. Chem. Pharm. Bid., 1995, 43, 884. #This paper is dedicated to the celebration of the 75th birthday of Dr. Yoshihisa Mizuno, Emeritus Professor of Hokkaido University.
影响因子：
56.9
作者：
WILSON, DK;RUDOLPH, FB;QUIOCHO, FA
通讯作者：
QUIOCHO, FA
腺苷脱氨酶在人类淋巴恶性肿瘤中的基因表达。
影响因子：
20.3
作者：
Gan,TE;Dadonna,PE;Mitchell,BS
通讯作者：
Mitchell,BS