Pluronic F127-micelles improve the stability and enhance the anticancer stem cell efficacy of citral in breast cancer
Pluronic F127-micelles improve the stability and enhance the anticancer stem cell efficacy of citral in breast cancer
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DOI：
10.2217/nnm-2021-0013
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发表时间：
2021-06-23
期刊：
影响因子：
5.5
通讯作者：
Schwartz, Simo, Jr.
中科院分区：
文献类型：
--
作者：
Abu-Serie, Marwa M.;Andrade, Fernanda;Schwartz, Simo, Jr.
目的：提高天然ALDH1A抑制剂柠檬醛的稳定性和抗肿瘤干细胞活性。材料和方法：使用Pluronic（R）F127获得柠檬醛负载的胶束（CLM），并测试其对四种乳腺癌细胞系的生长的功效。还使用乳腺球和CSC报告细胞系评价了CLM对乳腺CSC的生长和功能标志的影响。结果：CLM提高了柠檬醛的稳定性和生长抑制作用。重要的是，CLM完全阻断CSC的干细胞特征（自我更新、分化和迁移），并与紫杉醇CLM组合使乳腺癌细胞对化疗敏感。结论：CLM靶向肿瘤干细胞联合常规化疗可提高晚期乳腺癌的治疗效果。
Aim: Improving the stability and anti-cancer stem cell (CSC) activity of citral, a natural ALDH1A inhibitor. Materials & methods: Citral-loaded micelles (CLM) were obtained using Pluronic(R) F127 and its efficacy tested on the growth of four breast cancer cell lines. The impact of the CLM on the growth and functional hallmarks of breast CSCs were also evaluated using mammosphere and CSC reporter cell lines. Results: CLM improved the stability and growth inhibitory effects of citral. Importantly, CLM fully blocking the stemness features of CSCs (self-renewal, differentiation and migration) and in combination with paclitaxel CLM sensitized breast cancer cells to the chemotherapy. Conclusion: Targeting CSCs with CLM could improve the treatment of advanced breast cancer in combination with the standard chemotherapy.