The comorbidity of depression and substance use disorders
The comorbidity of depression and substance use disorders
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DOI：
10.1016/s0272-7358(99)00026-4
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发表时间：
2000-03-01
影响因子：
12.8
通讯作者：
Merikangas, KR
中科院分区：
文献类型：
--
作者：
Swendsen, JD;Merikangas, KR
抑郁症和药物使用障碍在普通人群中非常普遍，通常在同一个人体内同时发生。这种关联最常见的解释要么是因果关系，要么是两种疾病背后的共同病因。根据这些关联机制，本文总结了来自临床、流行病学和遗传流行病学研究的证据。还介绍了一项旨在解决审查中确定的关键方法和概念问题的大型家庭研究的详细情况。酒精中毒与抑郁症的联系很可能归因于偶然因素，而不是共同的病因，但关于其他类别的物质使用障碍的信息稀缺，排除了关于它们与抑郁症联系的类似结论。抑郁和物质使用障碍缺乏单向和一致的关联模式，这表明多种共病机制可能在这一人群中同时活跃。(C)2000爱思唯尔科学有限公司。
Depression and substance use disorders are highly prevalent in the general population and often co-occur within the same individual. This association is most commonly explained either by a causal relationship or a shared etiologic factor underlying both disorders. In light of these mechanisms of association, this article summarizes evidence from clinical, epidemiologic, and genetic epidemiologic studies. Details of a large family study designed to addresses key methodological and conceptual issues identified in the review are also presented. The association of alcoholism with depression is likely to be attributable to casual factors rather than a shared etiology, but the scarcity of information for other classes of substance use disorders precludes similar conclusions regarding their association with depression. The lack of unidirectional and consistent patterns of association for depression and substance use disorders indicates that multiple mechanisms of comorbidity are likely to be simultaneously active in this population. (C) 2000 Elsevier Science Ltd.