Analysis of the machinery and intermediates of the 5 hmC ‐ mediated DNA demethylation pathway in aging on samples from the-猫眼课题宝

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2016

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Valentini;Zampieri;Malavolta;Bacalini;Roberta;V. Calabrese;Guastafierro;Reale;Franceschi;Hervonen;Koller;Bernhardt;Slagboom;Toussaint;K Sikora;Gonos;Breusing;Grune;Jansen;Dollé;Moreno;Villanueva;Sindlinger;Bürkle;Ciccarone;Paola;Caiafa

对来自MARK-AGE研究的样本进行老化过程中5 hmC介导的DNA去甲基化途径的机制和中间体分析Elisabetta Valentini，Michele Zampieri，Marco Malavolta，Maria Giulia Bacalini，Roberta Calabrese，Tiziana Guastafierro，安娜Reale，Claudio Franceschi，Antti Hervonen，Bernhard Koller，Jürgen Bernhardt，P. Eline Slagboom，Olivier Toussaint，Ewa Sikora，Efstathios S. Gonos，Nicolle Breusing，Tilman Grune，Eugène Jansen，Martijn E.T. Dollé，María Moreno‐Villanueva，Thilo Sindlinger，亚历山大Bürkle，Fabio Ciccarone保拉Caiafa细胞生物技术和血液学系，药学和医学系，罗马大学，罗马00161，意大利巴斯德研究所-Fondazione Cenci Bolognetti，罗马00161，意大利国家老龄健康和科学研究所（INRCA），营养和老龄化中心，科学和技术研究区，60100安科纳，意大利博洛尼亚大学实验、诊断和专科医学系，博洛尼亚40126，意大利CIG-跨部门中心“L. Galvani”，阿尔马Mater Galvorum，博洛尼亚大学，40126博洛尼亚，意大利坦佩雷大学医学院，33014坦佩雷，芬兰大学教学医院蒂罗尔大厅，蒂罗尔，奥地利BioTeSys GmbH，73728 Esslingen，德国莱顿大学医学中心分子流行病学系，荷兰纳穆尔大学，细胞生物学研究单位，纳穆尔B-5000，比利时老化分子基础实验室，波兰科学院Nencki实验生物学研究所，02 - 093华沙，波兰国家希腊研究基金会，生物学、药物化学和生物技术研究所，希腊雅典，霍恩海姆大学营养医学研究所（180 c），70599 Stuttgart，Germany德国人类营养研究所波茨坦（DIfE），14558 Nuthetal，Germany国家公共卫生与环境研究所健康保护中心，3720 BA Bilthoven，荷兰康斯坦茨大学生物系分子毒理学组，78457 Konstanz，Germany罗马大学“Tor Vergata”生物系，00133罗马，意大利 * 共同的资深作者通信：保拉Caiafa;电子邮件：caiafa@bce.uniroma1.it

Analysis of the machinery and intermediates of the 5hmC‐mediated DNA demethylation pathway in aging on samples from the MARK‐ AGE Study Elisabetta Valentini, Michele Zampieri, Marco Malavolta, Maria Giulia Bacalini, Roberta Calabrese, Tiziana Guastafierro, Anna Reale, Claudio Franceschi, Antti Hervonen, Bernhard Koller, Jürgen Bernhardt, P. Eline Slagboom, Olivier Toussaint, Ewa Sikora, Efstathios S. Gonos, Nicolle Breusing, Tilman Grune, Eugène Jansen, Martijn E.T. Dollé, María Moreno‐Villanueva, Thilo Sindlinger, Alexander Bürkle, Fabio Ciccarone Paola Caiafa Department of Cellular Biotechnologies and Hematology, Faculty of Pharmacy and Medicine, Sapienza University of Rome, Rome 00161, Italy Pasteur Institute‐Fondazione Cenci Bolognetti, Rome 00161, Italy National Institute of Health and Science on Aging (INRCA), Nutrition and Ageing Centre, Scientific and Technological Research Area, 60100 Ancona, Italy Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum‐University of Bologna, Bologna 40126, Italy CIG‐Interdepartmental Center “L. Galvani”, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy The School of Medicine, The University of Tampere, 33014 Tampere, Finland Department for Internal Medicine, University Teaching Hospital Hall in Tirol, Tirol, Austria BioTeSys GmbH, 73728 Esslingen, Germany Department of Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands University of Namur, Research Unit on Cellular Biology, Namur B‐5000, Belgium Laboratory of the Molecular Bases of Ageing, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 02‐093 Warsaw, Poland National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, Athens, Greece Institute of Nutritional Medicine (180c), University of Hohenheim, 70599 Stuttgart, Germany German Institute of Human Nutrition Potsdam‐Rehbruecke (DIfE), 14558 Nuthetal, Germany Centre for Health Protection, National Institute for Public Health and the Environment, 3720 BA Bilthoven, The Netherlands Molecular Toxicology Group, Department of Biology, University of Konstanz, 78457 Konstanz, Germany Department of Biology, University of Rome "Tor Vergata", 00133 Rome, Italy *Shared senior authorship Correspondence to: Paola Caiafa; email: caiafa@bce.uniroma1.it

Analysis of the machinery and intermediates of the 5 hmC ‐ mediated DNA demethylation pathway in aging on samples from the

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