Acoustic response from adherent targeted contrast agents.
Acoustic response from adherent targeted contrast agents.
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DOI：
10.1121/1.2364303
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发表时间：
2006-12
期刊：
影响因子：
--
通讯作者：
Shukui Zhao;D. Kruse;K. Ferrara;P. Dayton
中科院分区：
文献类型：
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作者：
Shukui Zhao;D. Kruse;K. Ferrara;P. Dayton
在超声分子成像中，封装的微米级气泡通过靶向配体拴在血管壁上。一个具有挑战性的问题是检测粘附的微泡的回声，并将其与来自非粘附剂和组织的回声区分开。观察到来自粘附造影剂的回波包括基频处的高振幅，并且与游离造影剂相比具有显著不同的频谱形状（p <0.0003）。机制所观察到的声学差异和潜在的技术，利用这些差异的分子成像提出。
In ultrasonic molecular imaging, encapsulated micron-sized gas bubbles are tethered to a blood vessel wall by targeting ligands. A challenging problem is to detect the echoes from adherent microbubbles and distinguish them from echoes from nonadherent agents and tissue. Echoes from adherent contrast agents are observed to include a high amplitude at the fundamental frequency, and significantly different spectral shape compared with free agents (p <0.0003). Mechanisms for the observed acoustical difference and potential techniques to utilize these differences for molecular imaging are proposed.