A Pilot Validation Study of the Newborn Behavioral Observations System: Associations with Salivary Cortisol and Temperament.
A Pilot Validation Study of the Newborn Behavioral Observations System: Associations with Salivary Cortisol and Temperament.
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新生儿行为观察系统的试点验证研究：与唾液皮质醇和气质的关联。
DOI：
10.1097/dbp.0000000000000842
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发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Bush NR
中科院分区：
文献类型：
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作者：
Congdon JL;Nugent JK;McManus BM;Coccia M;Bush NR
有几个标准化的新生儿神经行为工具可用于纵向儿童发育研究。我们调整了已建立的临床工具，新生儿行为观察（NBO）系统，通过标准化管理协议和扩展三点编码量表到五点进行研究。我们对144名低收入妇女（平均年龄5周）所生的种族/民族多样化的晚期早产儿或足月儿进行了五点NBO。Cronbach的α计算，以确定内部一致性的自主性，运动，组织的状态，和响应分量表的可靠性。我们研究了并行效度与婴儿唾液皮质醇反应的NBO和母亲报告的婴儿气质的子量表协会。四个NBO分量表，组织的国家和响应度，分别有很好的（0.91）和良好的（0.76）的可靠性，并保留作进一步分析。国家组织得分较高（调节更优化）的婴儿表现出较低的皮质醇反应性（r =-0.30，p < 0.01）和气质消极性（r =-0.16，p < 0.05）。反应性与皮质醇反应性或气质无关。通过NBO五点量表测量的状态调节与婴儿对NBO管理的应激反应的生物标志物和报告的气质相关。NBO的三项自主和七项运动分量表的可靠性较差，这表明需要在其他样本中进行进一步的心理测量研究，并可能进行改进。鉴于婴儿神经行为评估工具的缺乏，这些发现证明了这些研究是朝着发展早期神经行为发育的实用，可靠和预测性措施的渐进式进展的下一步。
There are few standardized neonatal neurobehavioral instruments available for longitudinal child development research. We adapted the established clinical tool, the Newborn Behavioral Observations (NBO) system, for research by standardizing the administration protocol and expanding the three-point coding scale to five points. We administered the five-point NBO to 144 racially/ethnically diverse late-preterm or term infants born to low-income women (average age five weeks). Cronbach’s alphas were calculated to determine internal consistency reliability of Autonomic, Motor, Organization of State, and Responsivity subscales. We examined concurrent validity using subscale associations with infant salivary cortisol reactivity to the NBO and maternally reported infant temperament. Two of the four NBO subscales, Organization of State and Responsivity, had excellent (0.91) and good (0.76) reliability, respectively, and were retained for further analyses. Infants with higher Organization of State scores (more optimal regulation) demonstrated lower cortisol reactivity (r = −0.30, p < 0.01) and temperamental negativity (r = −0.16, p < 0.05). Responsivity was unrelated to cortisol reactivity or temperament. State regulation, as measured by the five-point NBO, was associated with a biologic marker of infant stress response to the NBO administration and reported temperament. Poor reliability of the NBO’s three-item Autonomic and seven-item Motor subscales suggests that further psychometric research in other samples, and likely refinement, are needed. Given the paucity of neurobehavioral assessment tools for infants, these findings justify such research as next steps in the incremental progression toward the development of a practical, reliable, and predictive measure of early neurobehavioral development.