SNYAPSIN-I IN NERVE-TERMINALS - SELECTIVE ASSOCIATION WITH SMALL SYNAPTIC VESICLES
SNYAPSIN-I IN NERVE-TERMINALS - SELECTIVE ASSOCIATION WITH SMALL SYNAPTIC VESICLES
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DOI：
10.1126/science.6438799
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发表时间：
1984-01-01
期刊：
影响因子：
56.9
通讯作者：
DECAMILLI, P
中科院分区：
文献类型：
--
作者：
NAVONE, F;GREENGARD, P;DECAMILLI, P
免疫细胞化学显示，突触蛋白I是优先（并可能专门）与小（40- 60 nm）突触囊泡，而不是与大（> 60 nm）致密核心囊泡在牛下丘脑。这些观察结果可以解释为什么突触蛋白I只在神经元中发现，因为小突触囊泡是神经元特有的，而神经元中的大致密核心囊泡可以被认为是内分泌细胞中的分泌细胞器的等价物。
Immunocytochemistry revealed that synapsin I is preferentially (and possibly exclusively) associated with small (40- to 60-nm) synaptic vesicles and not with large (> 60 nm) dense-core vesicles in bovine hypothalamus. These observations may explain why synapsin I is found exclusively in neurons, since small syaptic vesicles are specific to neurons whereas large dense-core vesicles in neurons may be considered the equivalent of secretory organelles in endocrine cells.