Prostate specific membrane antigen (PSMA) expression in non-small cell lung cancer.
Prostate specific membrane antigen (PSMA) expression in non-small cell lung cancer.
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DOI：
10.1371/journal.pone.0186280
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Huss S
中科院分区：
文献类型：
--
作者：
Schmidt LH;Heitkötter B;Schulze AB;Schliemann C;Steinestel K;Trautmann M;Marra A;Hillejan L;Mohr M;Evers G;Wardelmann E;Rahbar K;Görlich D;Lenz G;Berdel WE;Hartmann W;Wiewrodt R;Huss S
PSMA(前列腺特异性膜抗原)在前列腺癌细胞中过表达，被认为是转移性前列腺癌患者基于抗体的放射配基治疗的一个有前途的靶点。由于PSMA的表达并不局限于前列腺癌，因此基础研究调查了PSMA在非小细胞肺癌(NSCLC)中的表达。采用免疫组织化学方法检测275例非小细胞肺癌组织标本中PSMA的表达。采用CD34共表达法检测PSMA在肿瘤相关新生血管中的表达水平。评价PSMA表达对临床病理参数和预后的影响。PSMA瘤细胞在非小细胞肺癌中的表达低至6%，主要见于鳞癌(p=0.002)。新生血管PSMA在49%的非小细胞肺癌中表达。高新生血管PSMA表达与较高的肿瘤分级(G3/G4)相关(p<；0.001)。在所调查的NSCLC病例中，既没有PSMA肿瘤细胞的表达，也没有PSMA新生血管细胞的表达对预后的影响。在这里，我们报告了PSMA在非小细胞肺癌组织标本中的表达。在放射性标记PSMA配体潜在治疗的背景下，我们的数据可能有助于未来识别可能从这种治疗方案中受益的患者。
PSMA (prostate-specific membrane antigen) is overexpressed in prostate cancer cells and is reported to be a promising target for antibody-based radioligand therapy in patients with metastasized prostate cancer. Since PSMA expression is not restricted to prostate cancer, the underlying study investigates PSMA expression in non-small cell lung cancer (NSCLC). Immunohistochemistry was used to identify PSMA expression in n = 275 samples of NSCLC tissue specimens. By means of CD34 co-expression, the level of PSMA expression in tumor associated neovasculature was investigated. The impact of PSMA expression on clinicopathologic parameters and prognosis was evaluated. PSMA tumor cell expression in NSCLC is as low as 6% and was predominantly found in squamous cell carcinoma (p = 0.002). Neovascular PSMA expression was found in 49% of NSCLC. High neovascular PSMA expression was associated with higher tumor grading (G3/G4) (p < 0.001). Neither for PSMA tumor cell expression, nor for PSMA neovascular cell expression prognostic effects were found for the investigated NSCLC cases. Here, we report on the expression of PSMA in NSCLC tissue samples. Against the background of a potential treatment with radiolabeled PSMA ligands, our data might serve for the future identification of patients who could benefit from this therapeutic option.
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影响因子：
3.2
作者：
Ahmadzadehfar H;Rahbar K;Kürpig S;Bögemann M;Claesener M;Eppard E;Gärtner F;Rogenhofer S;Schäfers M;Essler M
通讯作者：
Essler M
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Rubin, Mark A.
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Rahbar, Kambiz;Weckesser, Matthias;Boegemann, Martin
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6.6
作者：
Bander, NH;Trabulsi, EJ;Goldsmith, SJ
通讯作者：
Goldsmith, SJ
影响因子：
9.8
作者：
Siemerink, Martin J.;Klaassen, Ingeborg;Vogels, Ilse M. C.;Griffioen, Arjan W.;Van Noorden, Cornelis J. F.;Schlingemann, Reinier O.
通讯作者：
Schlingemann, Reinier O.