IMMUNE-RESPONSE TO OUTER-MEMBRANE ANTIGENS OF MORAXELLA-CATARRHALIS IN CHILDREN WITH OTITIS-MEDIA
IMMUNE-RESPONSE TO OUTER-MEMBRANE ANTIGENS OF MORAXELLA-CATARRHALIS IN CHILDREN WITH OTITIS-MEDIA
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DOI：
10.1128/iai.60.9.3824-3829.1992
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发表时间：
1992-09-01
影响因子：
3.1
通讯作者：
MURPHY, T
中科院分区：
文献类型：
--
作者：
FADEN, H;HONG, J;MURPHY, T
本文报告14例中耳炎患儿对卡他莫拉菌同源株的全身和局部抗体反应。共有8名儿童（57%）表现出免疫球蛋白G（IgG）（5/14），IgM（5/14）或伊加（6/14）类免疫球蛋白的血清抗体升高外膜抗原。局部抗体以IgG（100%）、IgM（29%）、伊加（71%）为主。中耳积液中存在的IgG和伊加特异性抗体似乎代表局部产生，而不是从体循环被动扩散。这些数据表明，幼儿对M产生抗体反应。在中耳炎期间在中耳中产生卡他炎，但不能以均匀的方式产生全身性抗体。
The systemic and local antibody responses to homologous strains of Moraxella catarrhalis were investigated in 14 children with otitis media. A total of 8 children (57%) demonstrated a rise in serum antibody of the immunoglobulin G (IgG) (5 of 14), IgM (5 of 14), or IgA (6 of 14) classes of immunoglobulin to outer membrane antigens. Local antibody consisted of IgG (100%), IgM (29%), and IgA (71%). The IgG and IgA specific antibody present in middle-ear effusions appeared to represent local production rather than passive diffusion from the systemic circulation. These data suggest that young children develop an antibody response to M. catarrhalis in the middle ear during otitis media but fail to develop systemic antibody in a uniform manner.