Neurotransmitter Switching in the Adult Brain Regulates Behavior
Neurotransmitter Switching in the Adult Brain Regulates Behavior
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DOI：
10.1126/science.1234152
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发表时间：
2013-04-26
期刊：
影响因子：
56.9
通讯作者：
Spitzer, Nicholas C.
中科院分区：
文献类型：
--
作者：
Dulcis, Davide;Jamshidi, Pouya;Spitzer, Nicholas C.
神经递质被认为在整个生命过程中是固定的，但感官刺激是否会改变成熟大脑中与行为相关的递质表达尚不清楚。我们发现，在成年大鼠下丘脑的中间神经元之间切换多巴胺和生长抑素的表达响应暴露于短日照和长日照。突触后多巴胺受体表达的变化与突触前多巴胺的变化相匹配，而生长抑素受体表达保持不变。药理学阻断或消融这些多巴胺能神经元导致焦虑和抑郁的行为，phenocopying性能暴露于长日照光周期后。通过暴露于短日照光周期诱导新的多巴胺能神经元挽救了损伤的行为后果。其他感觉形态的自然刺激可能会导致调节不同行为的递质表达的变化。
Neurotransmitters have been thought to be fixed throughout life, but whether sensory stimuli alter behaviorally relevant transmitter expression in the mature brain is unknown. We found that populations of interneurons in the adult rat hypothalamus switched between dopamine and somatostatin expression in response to exposure to short- and long-day photoperiods. Changes in postsynaptic dopamine receptor expression matched changes in presynaptic dopamine, whereas somatostatin receptor expression remained constant. Pharmacological blockade or ablation of these dopaminergic neurons led to anxious and depressed behavior, phenocopying performance after exposure to the long-day photoperiod. Induction of newly dopaminergic neurons through exposure to the short-day photoperiod rescued the behavioral consequences of lesions. Natural stimulation of other sensory modalities may cause changes in transmitter expression that regulate different behaviors.