Regulation of free radical outflow from an isolated muscle bed in exercising humans
Regulation of free radical outflow from an isolated muscle bed in exercising humans
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DOI：
10.1152/ajpheart.00148.2004
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发表时间：
2004-10-01
影响因子：
4.8
通讯作者：
Richardson, RS
中科院分区：
文献类型：
--
作者：
Bailey, DM;Young, IS;Richardson, RS
递增膝伸肌（KE）运动进行单腿最大工作率（WRMAX）的25%，70%和100%结合离体电子顺磁共振（EPR）光谱检测α-苯基-叔丁基硝酮（PBN）加合物，脂质氢过氧化物（LH）和相关参数在5名男性。从股动脉和静脉循环中采集血液样本，当与股静脉血流量的测量变化相结合时，可以直接检查功能隔离的收缩肌床中的氧化剂交换。KE运动使LH和PBN加合物的净流出量逐渐增加（100%>70%> 25%WRMAX，P
Incremental knee extensor (KE) exercise performed at 25, 70, and 100% of single-leg maximal work rate (WRMAX) was combined with ex vivo electron paramagnetic resonance (EPR) spectroscopic detection of alpha-phenyl-tert-butylnitrone (PBN) adducts, lipid hydroperoxides (LH), and associated parameters in five males. Blood samples were taken from the femoral arterial and venous circulation that, when combined with measured changes in femoral venous blood flow, permitted a direct examination of oxidant exchange across a functionally isolated contracting muscle bed. KE exercise progressively increased the net outflow of LH and PBN adducts (100%>70%>25% WRMAX, P