Frequent Sugar-Sweetened Beverage Consumption and the Onset of Cardiometabolic Diseases: Cause for Concern?
Frequent Sugar-Sweetened Beverage Consumption and the Onset of Cardiometabolic Diseases: Cause for Concern?
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DOI：
10.1210/js.2017-00262
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发表时间：
2017-11-01
影响因子：
4.1
通讯作者：
Essop, M. Faadiel
中科院分区：
文献类型：
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作者：
Deshpande, Gaurang;Mapanga, Rudo F.;Essop, M. Faadiel
非传染性疾病发病率呈上升趋势，对全球公共卫生构成重大威胁。与此同时，全球各年龄段含糖饮料（SSBs）的摄入量也在稳步增长。由于几项研究证明了SSB摄入与代谢综合征（MetS）之间存在争议的关系，因此本文主要关注其摄入与(1)MetS,(2)糖尿病前期/ 2型糖尿病（T2DM）和(3)高血压之间的联系。对过去10年发表的临床和观察性研究进行了详细的搜索，使用将SSBs与MetS、T2DM和高血压联系起来的关键术语。在这里，我们排除了所有的荟萃分析和只关注肥胖的文献。分析显示，大多数流行病学研究强烈表明，从长远来看，频繁摄入SSB有助于met的发病。一些研究结果还表明，定期摄入SSB可以改变葡萄糖处理和胰岛素敏感性，从而促进MetS和T2DM的发展。也有证据表明，频繁摄入SSB（尤其是果糖）与高血压和众所周知的心血管疾病风险因素有关。然而，一些研究报告称，食用SSB没有负面影响。由于这种差异，我们建议精心设计的长期临床研究应进一步提高我们对SSB消费与心脏代谢疾病发病之间联系的理解。版权所有2017内分泌学会
The incidence of noncommunicable diseases is on the rise and poses a major threat to global public health. This is in parallel to a steady increase in worldwide intake of sugar-sweetened beverages (SSBs) among all age groups. As several studies demonstrated a controversial relationship between SSB consumption and the metabolic syndrome (MetS), this mini-review focuses on links between its intake and (1) MetS, (2) prediabetes/type 2 diabetes mellitus (T2DM), and (3) hypertension. A detailed search for clinical and observational studies published during the past 10 years was conducted using key terms that link SSBs to the MetS, T2DM, and hypertension. Here we excluded all meta-analyses and also literature that solely focused on obesity. The analysis revealed that most epidemiological studies strongly show that frequent SSB intake contributes to the onset of the MetS in the longer term. Some of the findings also show that regular SSB intake can alter glucose handling and insulin sensitivity, thereby contributing to the development of the MetS and T2DM. There is also evidence that frequent SSB intake (and particularly fructose) is linked to hypertension and well-known cardiovascular disease risk factors. However, some studies report on the lack of negative effects as a result of SSB consumption. Because of this discrepancy, we propose that well-designed long-term clinical studies should further enhance our understanding regarding the links between SSB consumption and the onset of cardiometabolic diseases. Copyright (c) 2017 Endocrine Society