Relationship of regional fat distribution and obesity to electrocardiographic parameters in healthy premenopausal women.
Relationship of regional fat distribution and obesity to electrocardiographic parameters in healthy premenopausal women.
复制标题
健康绝经前女性局部脂肪分布和肥胖与心电图参数的关系。
DOI：
10.1097/00007611-199108000-00007
复制
发表时间：
1991
影响因子：
1.1
通讯作者：
Kissebah,AH
中科院分区：
文献类型：
--
作者：
Peiris,AN;Thakur,RK;Sothmann,MS;Gustafson,AB;Hennes,MI;Wilson,CR;Kissebah,AH
腹型肥胖是一个独立的心血管危险因素。腹型肥胖与心电图异常的并存可能会促进心律失常和猝死的发生。我们确定了27名绝经前肥胖妇女在等热量饮食中体脂分布和肥胖与心电图指标的关系。通过计算机断层扫描评估腹腔内脂肪分布，通过静水称重评估肥胖。根据静息心电图确定PR、QRS和QTc间期、P和QRS轴以及P-QRS角。通过收缩压和舒张压以及血浆胆固醇和甘油三酯水平评估心血管风险状况。腹内脂肪沉积增加与QTc间期延长显著相关，与肥胖和其他心血管危险因素无关。随着腹内脂肪分布增加而观察到的QTc间期延长可能增加心律失常的易感性。这些受试者应在强化治疗方案实现体重减轻期间进行心电图监测。
Abdominal obesity is an independent cardiovascular risk factor. The coexistence of abdominal obesity and electrocardiographic abnormalities may facilitate the development of cardiac arrhythmias and sudden death. We determined the relationship of body fat distribution and obesity to ECG indices in 27 obese premenopausal women on an isocaloric diet. Intra-abdominal fat distribution was assessed by computerized tomography, and obesity was assessed by hydrostatic weighing. The PR, QRS, and QTc intervals, the P and QRS axes, and the P-QRS angle were determined from a resting electrocardiogram. Cardiovascular risk profile was assessed by systolic and diastolic blood pressure and plasma cholesterol and triglyceride levels. Increased deposition of intra-abdominal fat was significantly associated with prolongation of the QTc interval independent of obesity and other cardiovascular risk factors. The prolongation of the QTc interval seen with increasing intra-abdominal fat distribution may enhance susceptibility to cardiac arrhythmias. These subjects should have electrocardiographic monitoring during periods of weight loss achieved by intensive regimens.