Lewis acid-catalyzed nucleophilic substitutions of propargylic and allylic silyl ethers with enol silyl ethers.
Lewis acid-catalyzed nucleophilic substitutions of propargylic and allylic silyl ethers with enol silyl ethers.
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DOI：
10.1021/ol0271537
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发表时间：
2003-01
期刊：
影响因子：
5.2
通讯作者：
T. Ishikawa*;T. Aikawa;Yumiko Mori;S. Saito*
中科院分区：
文献类型：
--
作者：
T. Ishikawa*;T. Aikawa;Yumiko Mori;S. Saito*
研究了烯醇硅醚与炔丙基硅醚在刘易斯酸作用下生成的碳正离子的亲核反应。本发明的方法对于将丙二烯或烯炔官能团引入取代酮的α-位是非常有用的。[反应-见正文]
Nucleophilic reactions of various enol silyl ethers with carbocation species generated from propargyl silyl ethers by the action of a Lewis acid have been developed. The present method is highly useful for the introduction of allenic or enyne functionalities into the alpha-position of substituted ketones. [reaction--see text]