ERP study on the associations of peripheral oxytocin and prolactin with inhibitory processes involving emotional distraction
ERP study on the associations of peripheral oxytocin and prolactin with inhibitory processes involving emotional distraction
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DOI：
10.1186/s40101-019-0196-z
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发表时间：
2019-05-17
影响因子：
3.1
通讯作者：
Motomura, Yuki
中科院分区：
文献类型：
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作者：
Hayashi, Sayuri;Tsuru, Ayami;Motomura, Yuki
背景虐待儿童是一个重大的健康和社会福利问题，具有严重和长期的后果。冲动控制能力在降低儿童受虐待风险方面起着重要作用。本研究的目的是探讨催产素（OXT）和催乳素（PRL）与行为抑制的关系，使用儿童的面部表情（愤怒或中性）作为情绪干扰。这可能会澄清一部分的神经内分泌机制，调节冲动控制能力的上下文中的childbreving.MethodsParticipants是16名女性谁从来没有怀孕过。在静脉采血检测OXT和PRL水平后，参与者在卵泡期和黄体期进行情绪Go/Nogo任务，以测试抑制控制能力。行为表现和事件相关电位（ERPs）在task.ResultsThe结果表明，有显着的固定效应OXT对行为表现，作为衡量的敏感性（d-总理）。这表明，高外周OXT水平可能与情绪Go/Nogo任务的更好表现相关，无论情绪干扰因素如何。PRL与Nogo-N2和Nogo-P3所反映的抑制过程相关。特别是，高PRL水平与Nogo-N2潜伏期延长与情绪distractors.ConclusionsOur研究结果表明，OXT可能与改善行为表现，无论情绪过程。这表明，与PRL有关的过程与行为抑制和情绪的运动前活动有关。
BackgroundChild maltreatment is a major health and social welfare problem, with serious and longstanding consequences. Impulse control ability plays an important role in reducing the risk of child maltreatment. The aim of this study was to investigate the associations of oxytocin (OXT) and prolactin (PRL) with behavior inhibition using children's facial expressions (angry or neutral) as emotional distractions. This may clarify a part of the neuroendocrinological mechanism that modulates impulse control ability in the context of child caregiving.MethodsParticipants were 16 females who had never been pregnant. Following venous blood sampling for OXT and PRL levels, participants performed an emotional Go/Nogo task during their follicular and luteal phases to test inhibitory control ability. Behavioral performance and event-related potentials (ERPs) during the task were measured.ResultsThe results showed that there were significant fixed effects of OXT on behavioral performance, as measured by sensitivity (d-prime). This suggests that high peripheral OXT levels may be associated with better performance on the emotional Go/Nogo task, regardless of emotional distractors. PRL was associated with inhibitory processes as reflected by the Nogo-N2 and Nogo-P3. Particularly, high PRL levels were associated with the Nogo-N2 latency extension with the emotional distractors.ConclusionsOur findings suggest that OXT might be associated with improving behavioral performance regardless of emotional processes. It is suggested that processes related to PRL are related to premotor activities of behavioral inhibitions and emotions.