Carcinogenicity of organophosphorus pesticides/compounds: An analysis of their structure‐activity relationships 1
Carcinogenicity of organophosphorus pesticides/compounds: An analysis of their structure‐activity relationships 1
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DOI：
10.1080/10590509609373479
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发表时间：
1996-06
期刊：
影响因子：
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通讯作者：
Y. Woo;D. Lai;M. Argus;J. Arcos
中科院分区：
文献类型：
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作者：
Y. Woo;D. Lai;M. Argus;J. Arcos
合成有机磷化合物的大规模兴趣始于第二次世界大战期间，因为它们作为战争试剂的潜力。从那时起，有机磷化合物在工业、农业、医疗和消费方面有了各种应用。它们现在具有很大的经济重要性，因为它们被广泛用作杀虫剂。到目前为止，已经开发了大约200种有机磷农药（2）。除了农业应用，有机磷化合物已被用作阻燃剂，增塑剂，汽油添加剂，清洁剂，水1这篇综述已被写入支持文件的一部分，以开发一个基于知识规则的人工智能/专家系统，用于预测和/或评估化学化合物的致癌潜力（见参考文献1）。本文的内容已经过美国环境保护署污染预防和有毒物质办公室的审查和批准。批准并不意味着内容一定反映了该机构的观点或政策。
Large-scale interest in synthetic organophosphorus compounds started during World War II, because of their potential as warfare agents. Since then, various industrial, agricultural, medical and consumer applications have been found for organophosphorus compounds. They are now of great economic importance as they are extensively used as pesticides. About 200 organophosphorus pesticides have thus far been developed (2). Besides agricultural applications, organophosphorus compounds have been used as flame retardants, plasticizer, gasoline additives, cleaning agents, water1This review has been written as a part of support documents to develop a knowledge rule-based artificial intelligence/expert system for predicting and/or assessing the carcinogenic potential of chemical compounds (see ref. 1). The contents of this paper have been reviewed and approved by the US Environmental Protection Agency's Office of Pollution Prevention and Toxics. Approval does not signify that the contents necessarily reflect the views or policies of the Agency.