Neuregulin-1, a Key Axonal Signal that Drives Schwann Cell Growth and Differentiation
Neuregulin-1, a Key Axonal Signal that Drives Schwann Cell Growth and Differentiation
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DOI：
10.1002/glia.20753
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发表时间：
2008-11-01
期刊：
影响因子：
6.2
通讯作者：
Nave, Klaus-Armin
中科院分区：
文献类型：
--
作者：
Birchmeier, Carmen;Nave, Klaus-Armin
神经元和神经胶质细胞之间的相互作用对于建立功能性神经系统至关重要。许旺细胞发育和生理的许多方面都受到神经元信号的调节;可能最引人注目的是髓鞘的加工。一系列广泛的研究表明，一种称为“神经调节蛋白”的神经因子促进雪旺细胞生长和存活，沿着延伸的轴突迁移，以及髓鞘形成。因此，由这个因素引起的神经胶质反应的多样性显然是令人震惊的。(c)2008 Wiley-Liss，Inc.
Interactions between neuronal and glial cells are crucial for establishing a functional nervous system. Many aspects of Schwann cell development and physiology are regulated by neuronal signals; possibly the most spectacular is the elaboration of the myelin sheath. An extensive line of research has revealed that one neuronal factor, termed "neuregulin", promotes Schwann cell growth and survival, migration along the extending axon, and myelination. The versatility of glial responses elicited by this factor is thus clearly astounding. (c) 2008 Wiley-Liss, Inc.