RAS and ROS in rhabdomyosarcoma.

RAS and ROS in rhabdomyosarcoma.
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Ras和Ros中的横纹肌肉瘤。

DOI:
10.1016/j.ccr.2013.11.015
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发表时间:
2013-12-09
期刊:
影响因子:
50.3
通讯作者:
Kirsch DG
Kirsch DG
中科院分区:
医学1区
文献类型:
--
作者:
Zhang M;Linardic CM;Kirsch DG

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局限性横纹肌肉瘤的5年生存率超过70%,但转移性疾病患者的5年生存率仅为30%。在这一期的《癌细胞》中,Dyer及其同事对人类横纹肌肉瘤进行了全基因组和RNA测序,并确定RAS突变和氧化应激是高危胚胎横纹肌肉瘤的潜在治疗靶点。
The 5-year survival for localized rhabdomyosarcoma is over 70%, but only 30% for patients presenting with metastatic disease. In this issue of Cancer Cell, Dyer and colleagues performed whole-genome and RNA sequencing on human rhabdomyosarcoma and identified RAS mutations and oxidative stress as potential therapeutic targets for high-risk embryonal rhabdomyosarcoma.
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