Smoothness within ruggedness: The role of neutrality in adaptation
Smoothness within ruggedness: The role of neutrality in adaptation
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DOI：
10.1073/pnas.93.1.397
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发表时间：
1996-01-09
影响因子：
11.1
通讯作者：
Fontana, W
中科院分区：
文献类型：
--
作者：
Huynen, MA;Stadler, PF;Fontana, W
RNA二级结构折叠算法预测具有相同结构的RNA序列的连接网络的存在。在这样的网络上，进化的种群分裂成子种群，子种群在序列空间中独立扩散。这需要区分两个突变阈值：一个是基因信息丢失的阈值，一个是表型信息丢失的阈值。在这两者之间，扩散使得能够在保留显性表型的同时在基因空间中搜索大片区域，通过这种动态，表型适应的成功变得对基因空间中的初始条件不那么敏感。
RNA secondary structure folding algorithms predict the existence of connected networks of RNA sequences with identical structure. On such networks, evolving populations split into subpopulations, which diffuse independently in sequence space. This demands a distinction between two mutation thresholds: one at which genotypic information is lost and one at which phenotypic information is lost. In between, diffusion enables the search of vast areas in genotype space while still preserving the dominant phenotype, By this dynamic the success of phenotypic adaptation becomes much less sensitive to the initial conditions in genotype space.