Ridge reconstruction in damaged extraction sockets using tunnel β‐tricalcium phosphate blocks: A 6‐month histological study in beagle dogs
Ridge reconstruction in damaged extraction sockets using tunnel β‐tricalcium phosphate blocks: A 6‐month histological study in beagle dogs
复制标题
使用隧道 β-磷酸三钙块重建受损拔牙窝的牙槽嵴：一项为期 6 个月的比格犬组织学研究
DOI：
10.1111/jre.12735
复制
发表时间：
2020
影响因子：
3.5
通讯作者：
Iwata Takanori
中科院分区：
文献类型：
--
作者：
Ikawa Takahiro;Akizuki Tatsuya;Ono Wataru;Maruyama Kiichi;Okada Munehiro;Stavropoulos Andreas;Izumi Yuichi;Iwata Takanori
本研究旨在评估隧道β-TCP块移植在缺失颊侧骨壁的拔牙窝中6个月愈合后的组织学结果。背景在先前的狗研究中，由随机组织的隧道形β-TCP陶瓷制成的隧道β-磷酸三钙（β-TCP）块似乎有希望在缺失颊侧骨的拔牙窝中保留牙槽嵴，方法在6只比格犬中，拔除上颌第一前磨牙，手术切除颊侧骨，形成4 mm（近远中）× 5 mm（顶冠）× 4 mm（颊腭）的骨缺损。因此，缺失颊侧骨板的拔牙窝用隧道β-TCP块（试验组）打磨或留空以进行自发愈合（对照组）。组织学/histomorphometric进行后6个月的healing.ResultsThe水平颊腭宽度的牙槽嵴是显着大于在测试网站比对照网站。试验部位的矿化组织量（57.8% ± 11.1%）大于对照部位（28.9% ± 8.5%），而对照部位的结缔组织量（41.7% ± 6.4%）显著大于试验部位（19.6% ± 9.2%）。在基本多细胞单位和骨髓方面，未发现部位之间存在显著差异。结论与自行愈合的牙槽骨相比，使用隧道β-TCP块移植可显著限制缺失颊侧骨的拔牙窝牙槽嵴的吸收，即使在6个月的随访中也是如此。
ObjectiveThe present study aimed to evaluate the histological outcome of tunnel β‐TCP blocks grafting in extraction sockets missing the buccal bone wall, after 6 months of healing.BackgroundTunnel β‐tricalcium phosphate (β‐TCP) blocks made of randomly organized tunnel‐shaped β‐TCP ceramics appeared promising for alveolar ridge preservation in tooth extraction sockets missing the buccal bone, in a previous study in dogs, with a 2‐month healing time.MethodsIn six beagle dogs, the maxillary first premolars were extracted and the buccal bone was surgically removed to create bone defects of 4 mm (mesio‐distal) × 5 mm (apico‐coronal) × 4 mm (bucco‐palatal). Thus, extraction sockets missing the buccal bone plate were grated with tunnel β‐TCP blocks (test) or left empty for spontaneous healing (control). Histology/histomorphometry was performed after 6 months of healing.ResultsThe horizontal bucco‐palatal width of the alveolar ridge was significantly greater at test sites than at control sites. The amount of mineralized tissue was greater at test sites (57.8% ± 11.1%) than at control sites (28.9% ± 8.5%), while the amount of connective tissue was significantly greater at control sites (41.7% ± 6.4%) than at test sites (19.6% ± 9.2%). No significant difference was found between sites in terms of basic multicellular units and bone marrow. Residual β‐TCP at test sites was 5.8% ± 3.2%.ConclusionGrafting with tunnel β‐TCP block significantly limited the resorption of the alveolar ridge at extraction sockets missing the buccal bone compared with sites left to heal spontaneously, even after 6‐month follow‐up.