Interleukin 1 protects against 1-beta-D-arabinofuranosylcytosine-induced alopecia in the newborn rat animal model.
Interleukin 1 protects against 1-beta-D-arabinofuranosylcytosine-induced alopecia in the newborn rat animal model.
复制标题
在新生大鼠动物模型中，白细胞介素 1 可防止 1-β-D-阿拉伯呋喃糖基胞嘧啶诱导的脱发。
作者：
A. Hussein
脱发是癌症化疗最令人痛苦的心理副作用之一。在此之前，我们做了以下观察：(A)用1-β-D-阿拉伯糖胞嘧啶(Ara-C)、阿霉素和环磷酰胺(Cyc)治疗8日龄大鼠持续产生全身脱发(Ara-C和Cyc)或局限于头部和颈部近端的脱发(阿霉素)；(B)从粘质沙雷氏菌衍生的生物反应调节剂Imuvert对化疗诱导的脱发产生完全保护作用，但不是由CyC诱导的；以及(C)Imuvert对化疗诱导的脱发的保护作用是由单核细胞介导的细胞因子介导的。在本文报道的实验中，白细胞介素1被检测为潜在的细胞因子。白介素1对Ara-C诱导的新生大鼠脱发有良好的保护作用，但对CyC诱导的脱发没有明显的保护作用。
Alopecia is one of the most psychologically distressing side effects of cancer chemotherapy. Previously, we made the following observations: (a) treatment of 8-day-old rats with 1-beta-D-arabinofuranosylcytosine (ara-C), doxorubicin, and cyclophosphamide (CYC) consistently produced either total body alopecia (ara-C and CYC) or alopecia confined to the head and proximal part of the neck (doxorubicin); (b) Imuvert, a biological response modifier derived from the bacterium Serratia marcescens, uniformly produced complete protection against alopecia induced by ara-C and doxorubicin but not that induced by CYC; and (c) the protective effect of Imuvert against chemotherapy-induced alopecia is mediated by a monocyte-mediated cytokine. In the experiments reported here, interleukin 1 was examined as the potential cytokine. Interleukin 1 offered excellent protection against alopecia induced by ara-C but not that produced by CYC in the newborn rat animal model.