Increased colorectal cancer risk in first-degree relatives of patients with hyperplastic polyposis syndrome
Increased colorectal cancer risk in first-degree relatives of patients with hyperplastic polyposis syndrome
复制标题
DOI：
10.1136/gut.2009.200741
复制
发表时间：
2010-09-01
期刊：
影响因子：
24.5
通讯作者：
Dekker, E.
中科院分区：
文献类型：
--
作者：
Boparai, K. S.;Reitsma, J. B.;Dekker, E.
增生性息肉病综合征（HPS）的特征是存在多个结直肠增生性息肉，并与结直肠癌（CRC）风险增加有关。对于HPS患者的一级亲属（FDR），这尚未充分量化。可靠的证据有关的可能的过度风险的大小是必要的，以确定是否预防措施，如筛查结肠镜检查，在FDRs是justified.Aims和方法，我们分析了CRC的发病率在FDRs，并比较这与一般人群通过人-年分析调整后的人口统计学特征。埃因霍温癌症登记处在1970-2006年期间的人口为基础的发病率数据被用来比较观察到的CRC病例数在FDR与预期数字的基础上，在一般population.Results的发病率共347 FDR（41%男性）从57个家系，贡献11 053人年的后续行动。在研究期间，FDR中共发生27例CRC病例，而预期的CRC病例为5例（p
Introduction Hyperplastic polyposis syndrome (HPS) is characterised by the presence of multiple colorectal hyperplastic polyps and is associated with an increased colorectal cancer (CRC) risk. For first-degree relatives of HPS patients (FDRs) this has not been adequately quantified. Reliable evidence concerning the magnitude of a possible excess risk is necessary to determine whether preventive measures, like screening colonoscopies, in FDRs are justified.Aims and methods We analysed the incidence rate of CRC in FDRs and compared this with the general population through person-year analysis after adjustment for demographic characteristics. Population-based incidence data from the Eindhoven Cancer Registry during the period 1970-2006 were used to compare observed numbers of CRC cases in FDRs with expected numbers based on the incidence in the general population.Results A total of 347 FDRs (41% male) from 57 pedigrees were included, contributing 11 053 person-years of follow-up. During the study period, a total of 27 CRC cases occurred among FDRs compared to five expected CRC cases (p