Stronger associations of sagittal abdominal diameter with atherogenic lipoprotein subfractions than waist circumference in middle-aged US white and Japanese men
Stronger associations of sagittal abdominal diameter with atherogenic lipoprotein subfractions than waist circumference in middle-aged US white and Japanese men
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DOI：
10.1016/j.metabol.2010.04.019
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发表时间：
2010-12-01
影响因子：
9.8
通讯作者：
Sekikawa, Akira
中科院分区：
文献类型：
--
作者：
Nakata, Katsumi;Choo, Jina;Sekikawa, Akira
矢状腹径（SAD）和腰围（WC）与内脏脂肪组织（VAT）高度相关，而VAT与致动脉粥样硬化的脂蛋白谱有关。然而，它是不确定的SAD是否是一个更好的相关动脉粥样硬化脂蛋白亚组分比WC。我们研究了美国白色和日本男性SAD和WC与脂蛋白亚组分的相关性，同时研究了VAT和皮下脂肪组织与脂蛋白亚组分的相关性。以人群为基础的样本260白色和282日本男性，年龄在40至49岁，检查VAT和皮下脂肪组织的计算机断层扫描，SAD和WC的便携式滑动梁卡尺和卷尺，分别和脂蛋白亚组分的核磁共振光谱。对于白色和日本男性，SAD和WC均与大的极低密度脂蛋白、总的和小的低密度脂蛋白颗粒浓度显著正相关，与大的高密度脂蛋白颗粒浓度呈负相关。在身体质量指数调整回归模型中，SAD的显著相关性在白色和日本男性中仍然存在，而WC的相关性在白色男性中变得不显著。当SAD和WC同时纳入体重指数调整模型时，SAD的相关性仍然显著，并且在统计学上强于白色和日本男性的WC。此外，SAD与这些脂蛋白亚组分的关联模式与VAT的关联模式相当。在中年、非糖尿病、白色和日本男性中，胸腹直径与VAT相当，与致动脉粥样硬化脂蛋白亚组分的相关性强于WC。(C)2010年爱思唯尔公司All rights reserved.
Both sagittal abdominal diameter (SAD) and waist circumference (WC) highly correlate with visceral adipose tissue (VAT) being linked to an atherogenic lipoprotein profile. However, it is uncertain whether SAD is a better correlate of atherogenic lipoprotein subfractions than WC. We examined relative associations of SAD vs WC with lipoprotein subfractions for US white and Japanese men, concurrently examining the associations of VAT vs subcutaneous adipose tissue with lipoprotein subfractions. A population-based sample of 260 white and 282 Japanese men aged 40 to 49 years was examined for VAT and subcutaneous adipose tissue by computed tomography; SAD and WC by a portable sliding-beam caliper and a measuring tape, respectively; and lipoprotein subfractions by nuclear magnetic resonance spectroscopy. Both SAD and WC were significantly and positively associated with large very low-density lipoprotein and total and small low-density lipoprotein particle concentrations, and inversely associated with large high-density lipoprotein particle concentration for both white and Japanese men. In body mass index-adjusted regression models, the significant associations of SAD remained for both white and Japanese men, whereas those of WC became nonsignificant for white men. When SAD and WC were simultaneously included into the body mass index-adjusted models, the associations of SAD remained significant and statistically stronger than those of WC for both white and Japanese men. Furthermore, the pattern of the associations of SAD with those lipoprotein subfractions was comparable to that of the associations of VAT. Sagittal abdominal diameter was comparable to VAT and stronger than WC in the associations with atherogenic lipoprotein subfractions for middle-aged, nondiabetic, white and Japanese men. (C) 2010 Elsevier Inc. All rights reserved.