Principal cells of the brainstem's interaural sound level detector are temporal differentiators rather than integrators.
Principal cells of the brainstem's interaural sound level detector are temporal differentiators rather than integrators.
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DOI：
10.7554/elife.33854
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发表时间：
2018-06-14
期刊：
影响因子：
7.7
通讯作者：
Smith PH
中科院分区：
文献类型：
--
作者：
Franken TP;Joris PX;Smith PH
脑干外侧上级橄榄（LSO）被认为是通过编码耳间声级差（ILD）定位高频声音的关键。它的神经元权衡对侧抑制对同侧兴奋，使其放电率的声源的方位角位置的函数。自从第一次在体内记录以来，LSO主神经元已经被报道对持续的声音给出持续的和时间积分的“斩波器”响应。观察到具有短暂反应的神经元，但在很大程度上被忽视，甚至被认为是病理学的标志。使用蒙古沙鼠作为模型系统，我们已经获得了第一个在体内膜片钳记录标记的LSO神经元，并发现，主要LSO神经元，最多的投射神经元，这个核，只响应于声音发作，并显示快速的膜功能，表明时间的重要性。这些结果提供了一个新的框架来解释以前令人困惑的功能，该电路。
The brainstem’s lateral superior olive (LSO) is thought to be crucial for localizing high-frequency sounds by coding interaural sound level differences (ILD). Its neurons weigh contralateral inhibition against ipsilateral excitation, making their firing rate a function of the azimuthal position of a sound source. Since the very first in vivo recordings, LSO principal neurons have been reported to give sustained and temporally integrating ‘chopper’ responses to sustained sounds. Neurons with transient responses were observed but largely ignored and even considered a sign of pathology. Using the Mongolian gerbil as a model system, we have obtained the first in vivo patch clamp recordings from labeled LSO neurons and find that principal LSO neurons, the most numerous projection neurons of this nucleus, only respond at sound onset and show fast membrane features suggesting an importance for timing. These results provide a new framework to interpret previously puzzling features of this circuit.