Dopamine and noradrenaline efflux in the rat prefrontal cortex after classical aversive conditioning to an auditory cue
Dopamine and noradrenaline efflux in the rat prefrontal cortex after classical aversive conditioning to an auditory cue
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DOI：
10.1046/j.0953-816x.2001.01471.x
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发表时间：
2001-03-01
影响因子：
3.4
通讯作者：
de Bruin, JPC
中科院分区：
文献类型：
--
作者：
Feenstra, MGP;Vogel, M;de Bruin, JPC
我们使用双边微透析在清醒的内侧前额叶皮层（PFC），自由活动的大鼠研究厌恶条件反射的听觉线索在斯金纳箱的受控环境。先前与足部电击相关的明确条件刺激（CS）的呈现引起多巴胺（DA）和去甲肾上腺素（NA）流出增加。这种条件反应是依赖于两个刺激的立即配对;在pseudoconditioned组，收到了相同数量的两个刺激，但在一个不配对的方式，没有条件增加外排进行了观察。
We used bilateral microdialysis in the medial prefrontal cortex (PFC) of awake, freely moving rats to study aversive conditioning to an auditory cue in the controlled environment of the Skinner box. The presentation of the explicit conditioned stimuli (CS), previously associated with foot shocks, caused increased dopamine (DA) and noradrenaline (NA) efflux. This conditioned response was dependent on the immediate pairing of the two stimuli; in the pseudoconditioned group that received an equal number of both stimuli, but in an unpaired fashion, no conditioned increases in efflux were observed.